Next-Generation Sequencing in Order to Better Characterize a BRCA Variant of Uncertain Significance

Next-Generation Sequencing in Order to Better Characterize a BRCA Variant of Uncertain Significance

BRCA germline mutations are the most common predisposing factor in familial breast-ovarian cancer syndrome families. However, many screened patients are identified as harboring BRCA variants of uncertain significance (VUS), rather than carrying deleterious germline mutations [Calo et al.: Cancers 20...

Full description

Bibliographic Details
Main Authors: Steven Sorscher, Shakti Ramkissoon
Format: Article
Language:English
Published: Karger Publishers 2017-07-01
Series:Case Reports in Oncology
Subjects:
BRCA variant
Variant of uncertain significance
Next-generation sequencing
Online Access:http://www.karger.com/Article/FullText/478005

Internet

http://www.karger.com/Article/FullText/478005

Similar Items