Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy

Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy

ABSTRACTThe incidence of isoniazid (INH) resistant Mycobacterium tuberculosis is increasing globally. This study aimed to identify the molecular mechanisms behind the development of INH resistance in M. tuberculosis strains collected from the same patients during the standard course of treatment. Th...

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Main Authors: Ketema Tafess, Timothy Ting-Leung Ng, Kingsley King-Gee Tam, Kenneth Siu-Sing Leung, Jake Siu-Lun Leung, Lam-Kwong Lee, Hiu Yin Lao, Chloe Toi-Mei Chan, Wing-Cheong Yam, Samson Sai Yin Wong, Terrence Chi-Kwong Lau, Gilman Kit-Hang Siu
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
isoniazid resistance
Mycobacterium tuberculosis
whole-genome sequencing
transformation
antituberculosis treatment
protein modeling
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02133-23

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