Cerebellar Kainate Receptor-Mediated Facilitation of Glutamate Release Requires Ca2+-Calmodulin and PKA

Cerebellar Kainate Receptor-Mediated Facilitation of Glutamate Release Requires Ca2+-Calmodulin and PKA

We elucidated the mechanisms underlying the kainate receptor (KAR)-mediated facilitatory modulation of synaptic transmission in the cerebellum. In cerebellar slices, KA (3 μM) increased the amplitude of evoked excitatory postsynaptic currents (eEPSCs) at synapses between axon terminals of parallel f...

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Bibliographic Details
Main Authors: Rafael Falcón-Moya, Pilar Losada-Ruiz, Talvinder S. Sihra, Antonio Rodríguez-Moreno
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
kainate receptors
glutamate
presynaptic
Ca2+-calmodulin
PKA
slices
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00195/full

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