Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer
Triple negative breast cancer: Obesity and metabolism fuel disease spread Metabolic changes contribute to the metastatic potential of triple negative breast cancer (TNBC), a mouse study shows. Stephen Hursting and colleagues from the University of North Carolina at Chapel Hill, USA, established meta...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-07-01
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| Series: | npj Breast Cancer |
| Online Access: | https://doi.org/10.1038/s41523-017-0027-5 |
| _version_ | 1797641199180316672 |
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| author | Ciara H. O’Flanagan Emily L. Rossi Shannon B. McDonell Xuewen Chen Yi-Hsuan Tsai Joel S. Parker Jerry Usary Charles M. Perou Stephen D. Hursting |
| author_facet | Ciara H. O’Flanagan Emily L. Rossi Shannon B. McDonell Xuewen Chen Yi-Hsuan Tsai Joel S. Parker Jerry Usary Charles M. Perou Stephen D. Hursting |
| author_sort | Ciara H. O’Flanagan |
| collection | DOAJ |
| description | Triple negative breast cancer: Obesity and metabolism fuel disease spread Metabolic changes contribute to the metastatic potential of triple negative breast cancer (TNBC), a mouse study shows. Stephen Hursting and colleagues from the University of North Carolina at Chapel Hill, USA, established metastatic mouse TNBC cells driven by Wnt-1, a signaling protein that’s highly active in this aggressive subtype of breast cancer. In a lab dish, these cells showed signs of increased invasiveness; and when transplanted into mice, the cells readily formed tumors that metastasized to the lungs. Obese mice experienced more aggressive tumor growth and spread than normal-weight animals. Gene expression analyses revealed that TNBC cells with metastatic potential have an energetic leg-up over their non-metastatic counterparts in the face of obesity-induced metabolic changes, suggesting that targeting metabolic perturbations could help reduce the burden of metastatic TNBC, particularly for obese women. |
| first_indexed | 2024-03-11T13:42:08Z |
| format | Article |
| id | doaj.art-3ffbeeb5d8f0457d99bab6179b071ed7 |
| institution | Directory Open Access Journal |
| issn | 2374-4677 |
| language | English |
| last_indexed | 2024-03-11T13:42:08Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Breast Cancer |
| spelling | doaj.art-3ffbeeb5d8f0457d99bab6179b071ed72023-11-02T11:35:08ZengNature Portfolionpj Breast Cancer2374-46772017-07-013111110.1038/s41523-017-0027-5Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancerCiara H. O’Flanagan0Emily L. Rossi1Shannon B. McDonell2Xuewen Chen3Yi-Hsuan Tsai4Joel S. Parker5Jerry Usary6Charles M. Perou7Stephen D. Hursting8Department of Nutrition, University of North CarolinaDepartment of Nutrition, University of North CarolinaDepartment of Nutrition, University of North CarolinaDepartment of Nutrition, University of North CarolinaLineberger Comprehensive Cancer Center, University of North CarolinaLineberger Comprehensive Cancer Center, University of North CarolinaLineberger Comprehensive Cancer Center, University of North CarolinaLineberger Comprehensive Cancer Center, University of North CarolinaDepartment of Nutrition, University of North CarolinaTriple negative breast cancer: Obesity and metabolism fuel disease spread Metabolic changes contribute to the metastatic potential of triple negative breast cancer (TNBC), a mouse study shows. Stephen Hursting and colleagues from the University of North Carolina at Chapel Hill, USA, established metastatic mouse TNBC cells driven by Wnt-1, a signaling protein that’s highly active in this aggressive subtype of breast cancer. In a lab dish, these cells showed signs of increased invasiveness; and when transplanted into mice, the cells readily formed tumors that metastasized to the lungs. Obese mice experienced more aggressive tumor growth and spread than normal-weight animals. Gene expression analyses revealed that TNBC cells with metastatic potential have an energetic leg-up over their non-metastatic counterparts in the face of obesity-induced metabolic changes, suggesting that targeting metabolic perturbations could help reduce the burden of metastatic TNBC, particularly for obese women.https://doi.org/10.1038/s41523-017-0027-5 |
| spellingShingle | Ciara H. O’Flanagan Emily L. Rossi Shannon B. McDonell Xuewen Chen Yi-Hsuan Tsai Joel S. Parker Jerry Usary Charles M. Perou Stephen D. Hursting Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer npj Breast Cancer |
| title | Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer |
| title_full | Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer |
| title_fullStr | Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer |
| title_full_unstemmed | Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer |
| title_short | Metabolic reprogramming underlies metastatic potential in an obesity-responsive murine model of metastatic triple negative breast cancer |
| title_sort | metabolic reprogramming underlies metastatic potential in an obesity responsive murine model of metastatic triple negative breast cancer |
| url | https://doi.org/10.1038/s41523-017-0027-5 |
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