Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface Properties
Abstract Infections are a significant risk to patients who receive medical implants, and can often lead to implant failure, tissue necrosis, and even amputation. So far, although various surface modification approaches are proposed for prevention and treatment of microbial biofilms on indwelling med...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-06-01
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| Series: | Advanced Materials Interfaces |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/admi.202202350 |
| _version_ | 1797736674423209984 |
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| author | Mohammad Asadi Tokmedash Neha Nagpal Po‐Yen Chen J. Scott VanEpps Jouha Min |
| author_facet | Mohammad Asadi Tokmedash Neha Nagpal Po‐Yen Chen J. Scott VanEpps Jouha Min |
| author_sort | Mohammad Asadi Tokmedash |
| collection | DOAJ |
| description | Abstract Infections are a significant risk to patients who receive medical implants, and can often lead to implant failure, tissue necrosis, and even amputation. So far, although various surface modification approaches are proposed for prevention and treatment of microbial biofilms on indwelling medical devices, most are too expensive/complicated to fabricate, unscalable, or limited in durability for clinical use. Here, this work presents a new bottom‐up design for fabricating scalable and durable nano‐patterned coatings with dynamic topography for long‐term antibacterial effects. This work shows that MXene layer‐by‐layer (LbL) self‐assembled coatings—with finely tunable crumpled structures with nanometer resolution and excellent mechanical durability—can be successfully fabricated on stretchable poly(dimethylsiloxane) (PDMS). The crumpled MXene coating with sharp‐edged peaks shows potent antibacterial effects against Staphylococcus aureus and Escherichia coli. In addition, this work finds that on‐demand dynamic deformation of the crumpled coating can remove ≥99% of adhered bacterial cells for both species, resulting in a clean surface with restored functionality. This approach offers improved practicality, scalability, and antibacterial durability over previous methods, and its flexibility may lend itself to many types of biomaterials and implantable devices. |
| first_indexed | 2024-03-12T13:17:18Z |
| format | Article |
| id | doaj.art-3ffc6adc03d14e67b0d3bab6bb30b955 |
| institution | Directory Open Access Journal |
| issn | 2196-7350 |
| language | English |
| last_indexed | 2024-03-12T13:17:18Z |
| publishDate | 2023-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj.art-3ffc6adc03d14e67b0d3bab6bb30b9552023-08-26T12:45:57ZengWiley-VCHAdvanced Materials Interfaces2196-73502023-06-011016n/an/a10.1002/admi.202202350Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface PropertiesMohammad Asadi Tokmedash0Neha Nagpal1Po‐Yen Chen2J. Scott VanEpps3Jouha Min4Department of Chemical Engineering University of Michigan Ann Arbor MI 48109 USADepartment of Chemical Engineering University of Michigan Ann Arbor MI 48109 USADepartment of Chemical and Biomolecular Engineering University of Maryland College Park MD 20742 USADepartment of Emergency Medicine University of Michigan Ann Arbor MI 48109 USADepartment of Chemical Engineering University of Michigan Ann Arbor MI 48109 USAAbstract Infections are a significant risk to patients who receive medical implants, and can often lead to implant failure, tissue necrosis, and even amputation. So far, although various surface modification approaches are proposed for prevention and treatment of microbial biofilms on indwelling medical devices, most are too expensive/complicated to fabricate, unscalable, or limited in durability for clinical use. Here, this work presents a new bottom‐up design for fabricating scalable and durable nano‐patterned coatings with dynamic topography for long‐term antibacterial effects. This work shows that MXene layer‐by‐layer (LbL) self‐assembled coatings—with finely tunable crumpled structures with nanometer resolution and excellent mechanical durability—can be successfully fabricated on stretchable poly(dimethylsiloxane) (PDMS). The crumpled MXene coating with sharp‐edged peaks shows potent antibacterial effects against Staphylococcus aureus and Escherichia coli. In addition, this work finds that on‐demand dynamic deformation of the crumpled coating can remove ≥99% of adhered bacterial cells for both species, resulting in a clean surface with restored functionality. This approach offers improved practicality, scalability, and antibacterial durability over previous methods, and its flexibility may lend itself to many types of biomaterials and implantable devices.https://doi.org/10.1002/admi.202202350antibacterial surfacescrumple structuresdynamic topographylayer‐by‐layer assemblyMXene |
| spellingShingle | Mohammad Asadi Tokmedash Neha Nagpal Po‐Yen Chen J. Scott VanEpps Jouha Min Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface Properties Advanced Materials Interfaces antibacterial surfaces crumple structures dynamic topography layer‐by‐layer assembly MXene |
| title | Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface Properties |
| title_full | Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface Properties |
| title_fullStr | Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface Properties |
| title_full_unstemmed | Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface Properties |
| title_short | Stretchable, Nano‐Crumpled MXene Multilayers Impart Long‐Term Antibacterial Surface Properties |
| title_sort | stretchable nano crumpled mxene multilayers impart long term antibacterial surface properties |
| topic | antibacterial surfaces crumple structures dynamic topography layer‐by‐layer assembly MXene |
| url | https://doi.org/10.1002/admi.202202350 |
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