A Prospective Study of Asymptomatic Intracranial Atherosclerotic Stenosis in Neurologically Normal Volunteers in a Japanese Cohort
Atherosclerotic stenosis of major intracranial arteries is a leading cause of ischemic stroke in Asia. However, the long-term prognosis of asymptomatic intracranial atherosclerotic stenosis (ICAS) in healthy volunteers has not been fully examined. Here we conducted a longitudinal study to examine th...
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| Format: | Article |
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Frontiers Media S.A.
2016-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00039/full |
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| author | Ryukichi eMatsui Ryukichi eMatsui Tomonori eNakagawa Hiroyuki eTakayoshi Keiichi eOnoda Hiroaki eOguro Atsushi eNagai Shuhei eYamaguchi |
| author_facet | Ryukichi eMatsui Ryukichi eMatsui Tomonori eNakagawa Hiroyuki eTakayoshi Keiichi eOnoda Hiroaki eOguro Atsushi eNagai Shuhei eYamaguchi |
| author_sort | Ryukichi eMatsui |
| collection | DOAJ |
| description | Atherosclerotic stenosis of major intracranial arteries is a leading cause of ischemic stroke in Asia. However, the long-term prognosis of asymptomatic intracranial atherosclerotic stenosis (ICAS) in healthy volunteers has not been fully examined. Here we conducted a longitudinal study to examine the prognosis of healthy volunteers with asymptomatic ICAS and to determine the risk factors for ICAS, including asymptomatic brain parenchymal lesions. We studied 2,807 healthy Japanese volunteers with no history of stroke (mean age, 62.0 years). They were followed for a mean interval of 64.5 months. The degree of ICAS and the presence of asymptomatic brain lesions were assessed by using magnetic resonance imaging. Asymptomatic ICAS was detected in 166 volunteers (5.9%) at the initial examination. Moderate and mild stenoses were observed in 1.5% and 4.4% of patients, respectively. Significant risk factors for ICAS were older age and a history of hypertension, and/or dyslipidemia. During follow-up, ischemic stroke developed in 32 volunteers. Seven strokes occurred in the ICAS group, whose stroke incidence rate was higher than that in the non-ICAS group (0.78% vs. 0.18% per year). According to a Cox regression analysis, asymptomatic ICAS was an independent risk factor for future ischemic stroke after adjustment for age. Furthermore, after asymptomatic brain lesions were taken into account, ICAS was still a significant risk factor for stroke onset. In conclusion, even mild to moderate asymptomatic ICAS was a significant risk factor for future stroke, independent of asymptomatic brain lesions, in a healthy Japanese population. Mild to moderate ICAS might be a therapeutic target for stroke prevention. |
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| language | English |
| last_indexed | 2024-04-13T15:23:08Z |
| publishDate | 2016-03-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-3ffc70ee9f1e4fea9d64fa1b420565312022-12-22T02:41:35ZengFrontiers Media S.A.Frontiers in Neurology1664-22952016-03-01710.3389/fneur.2016.00039185353A Prospective Study of Asymptomatic Intracranial Atherosclerotic Stenosis in Neurologically Normal Volunteers in a Japanese CohortRyukichi eMatsui0Ryukichi eMatsui1Tomonori eNakagawa2Hiroyuki eTakayoshi3Keiichi eOnoda4Hiroaki eOguro5Atsushi eNagai6Shuhei eYamaguchi7Shimane UniversityMasuda Red Cross HospitalShimane UniversityShimane UniversityShimane UniversityShimane UniversityShimane UniversityShimane UniversityAtherosclerotic stenosis of major intracranial arteries is a leading cause of ischemic stroke in Asia. However, the long-term prognosis of asymptomatic intracranial atherosclerotic stenosis (ICAS) in healthy volunteers has not been fully examined. Here we conducted a longitudinal study to examine the prognosis of healthy volunteers with asymptomatic ICAS and to determine the risk factors for ICAS, including asymptomatic brain parenchymal lesions. We studied 2,807 healthy Japanese volunteers with no history of stroke (mean age, 62.0 years). They were followed for a mean interval of 64.5 months. The degree of ICAS and the presence of asymptomatic brain lesions were assessed by using magnetic resonance imaging. Asymptomatic ICAS was detected in 166 volunteers (5.9%) at the initial examination. Moderate and mild stenoses were observed in 1.5% and 4.4% of patients, respectively. Significant risk factors for ICAS were older age and a history of hypertension, and/or dyslipidemia. During follow-up, ischemic stroke developed in 32 volunteers. Seven strokes occurred in the ICAS group, whose stroke incidence rate was higher than that in the non-ICAS group (0.78% vs. 0.18% per year). According to a Cox regression analysis, asymptomatic ICAS was an independent risk factor for future ischemic stroke after adjustment for age. Furthermore, after asymptomatic brain lesions were taken into account, ICAS was still a significant risk factor for stroke onset. In conclusion, even mild to moderate asymptomatic ICAS was a significant risk factor for future stroke, independent of asymptomatic brain lesions, in a healthy Japanese population. Mild to moderate ICAS might be a therapeutic target for stroke prevention.http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00039/fullMagnetic Resonance AngiographyRisk factorslongitudinal studyasymptomatic brain lesionsasymptomatic intracranial atherosclerotic stenosis |
| spellingShingle | Ryukichi eMatsui Ryukichi eMatsui Tomonori eNakagawa Hiroyuki eTakayoshi Keiichi eOnoda Hiroaki eOguro Atsushi eNagai Shuhei eYamaguchi A Prospective Study of Asymptomatic Intracranial Atherosclerotic Stenosis in Neurologically Normal Volunteers in a Japanese Cohort Frontiers in Neurology Magnetic Resonance Angiography Risk factors longitudinal study asymptomatic brain lesions asymptomatic intracranial atherosclerotic stenosis |
| title | A Prospective Study of Asymptomatic Intracranial Atherosclerotic Stenosis in Neurologically Normal Volunteers in a Japanese Cohort |
| title_full | A Prospective Study of Asymptomatic Intracranial Atherosclerotic Stenosis in Neurologically Normal Volunteers in a Japanese Cohort |
| title_fullStr | A Prospective Study of Asymptomatic Intracranial Atherosclerotic Stenosis in Neurologically Normal Volunteers in a Japanese Cohort |
| title_full_unstemmed | A Prospective Study of Asymptomatic Intracranial Atherosclerotic Stenosis in Neurologically Normal Volunteers in a Japanese Cohort |
| title_short | A Prospective Study of Asymptomatic Intracranial Atherosclerotic Stenosis in Neurologically Normal Volunteers in a Japanese Cohort |
| title_sort | prospective study of asymptomatic intracranial atherosclerotic stenosis in neurologically normal volunteers in a japanese cohort |
| topic | Magnetic Resonance Angiography Risk factors longitudinal study asymptomatic brain lesions asymptomatic intracranial atherosclerotic stenosis |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00039/full |
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