The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia
Artemisia argyi and Artemisia indica are edible medicinal plants belonging to the genus Artemisia in the Asteraceae. There are many similarities in their morphology, traditional curative effect, and modern pharmacological treatment. In this study, we built distribution maps of A. argyi and A. indica...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2022.949743/full |
| _version_ | 1798039037001334784 |
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| author | Zhanhu Cui Zhanhu Cui Siqi Li Jiayin Chang Erhuan Zang Qian Liu Baochang Zhou Chao Li Mengzhi Li Xianzhang Huang Zhongyi Zhang Minhui Li Minhui Li Minhui Li |
| author_facet | Zhanhu Cui Zhanhu Cui Siqi Li Jiayin Chang Erhuan Zang Qian Liu Baochang Zhou Chao Li Mengzhi Li Xianzhang Huang Zhongyi Zhang Minhui Li Minhui Li Minhui Li |
| author_sort | Zhanhu Cui |
| collection | DOAJ |
| description | Artemisia argyi and Artemisia indica are edible medicinal plants belonging to the genus Artemisia in the Asteraceae. There are many similarities in their morphology, traditional curative effect, and modern pharmacological treatment. In this study, we built distribution maps of A. argyi and A. indica in China and a phylogenetic tree of common medicinal plants in Asteraceae. Then, we verified the chemical composition changes of A. argyi and A. indica via their metabolome. Traditional efficacy and modern pharmacological action were verified by network pharmacology and in vitro using RAW264.7 cells. The results showed that A. argyi and A. indica are widely distributed in China, and they shared pharmaphylogeny, which provides theoretical support for the mixed use of A. argyi and A. indica in most regions of China. Furthermore, there were both similarities and differences in volatile oil and flavonoid composition between A. argyi and A. indica. The network pharmacology results showed that A. argyi and A. indica had 23 common active compounds and that both had pharmacological effects on chronic gastritis (CG). Molecular docking analyses showed that quercetin, luteolin, and kaempferol have strong binding affinities with the target proteins JUN, TP53, AKT1, MAPK3, TNF, MAPK, and IL6. The cell experiment results further demonstrated that A. argyi and A. indica treat CG via the NOD-like receptor pathway. Based on the theory of pharmaphylogeny, this study explored the pharmaphylogeny between A. argyi and A. indica from various perspectives to provide a basis for the substitution of A. argyi and A. indica. |
| first_indexed | 2024-04-11T21:49:19Z |
| format | Article |
| id | doaj.art-3ffcb9148b434f2683f41298fd35621d |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-04-11T21:49:19Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-3ffcb9148b434f2683f41298fd35621d2022-12-22T04:01:18ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2022-08-011310.3389/fpls.2022.949743949743The pharmacophylogenetic relationships of two edible medicinal plants in the genus ArtemisiaZhanhu Cui0Zhanhu Cui1Siqi Li2Jiayin Chang3Erhuan Zang4Qian Liu5Baochang Zhou6Chao Li7Mengzhi Li8Xianzhang Huang9Zhongyi Zhang10Minhui Li11Minhui Li12Minhui Li13College of Agriculture, Fujian Agriculture and Forestry University, Fuzhou, ChinaThe First People’s Hospital of Nanyang Affiliated to Henan University, Nanyang, ChinaInner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Baotou Medical College, Baotou, ChinaInner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Baotou Medical College, Baotou, ChinaInner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Baotou Medical College, Baotou, ChinaInner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Baotou Medical College, Baotou, ChinaCollege of Traditional Chinese Medicine, Inner Mongolia Medical University, Hohhot, ChinaNanyang Institute of Technology, Nanyang, ChinaNanyang Institute of Technology, Nanyang, ChinaNanyang Institute of Technology, Nanyang, ChinaCollege of Agriculture, Fujian Agriculture and Forestry University, Fuzhou, ChinaInner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Baotou Medical College, Baotou, ChinaCollege of Traditional Chinese Medicine, Inner Mongolia Medical University, Hohhot, ChinaInner Mongolia Hospital of Traditional Chinese Medicine, Hohhot, ChinaArtemisia argyi and Artemisia indica are edible medicinal plants belonging to the genus Artemisia in the Asteraceae. There are many similarities in their morphology, traditional curative effect, and modern pharmacological treatment. In this study, we built distribution maps of A. argyi and A. indica in China and a phylogenetic tree of common medicinal plants in Asteraceae. Then, we verified the chemical composition changes of A. argyi and A. indica via their metabolome. Traditional efficacy and modern pharmacological action were verified by network pharmacology and in vitro using RAW264.7 cells. The results showed that A. argyi and A. indica are widely distributed in China, and they shared pharmaphylogeny, which provides theoretical support for the mixed use of A. argyi and A. indica in most regions of China. Furthermore, there were both similarities and differences in volatile oil and flavonoid composition between A. argyi and A. indica. The network pharmacology results showed that A. argyi and A. indica had 23 common active compounds and that both had pharmacological effects on chronic gastritis (CG). Molecular docking analyses showed that quercetin, luteolin, and kaempferol have strong binding affinities with the target proteins JUN, TP53, AKT1, MAPK3, TNF, MAPK, and IL6. The cell experiment results further demonstrated that A. argyi and A. indica treat CG via the NOD-like receptor pathway. Based on the theory of pharmaphylogeny, this study explored the pharmaphylogeny between A. argyi and A. indica from various perspectives to provide a basis for the substitution of A. argyi and A. indica.https://www.frontiersin.org/articles/10.3389/fpls.2022.949743/fullArtemisia argyiArtemisia indicapharmaphylogenymetabolomicsnetwork pharmacologyinflammation |
| spellingShingle | Zhanhu Cui Zhanhu Cui Siqi Li Jiayin Chang Erhuan Zang Qian Liu Baochang Zhou Chao Li Mengzhi Li Xianzhang Huang Zhongyi Zhang Minhui Li Minhui Li Minhui Li The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia Frontiers in Plant Science Artemisia argyi Artemisia indica pharmaphylogeny metabolomics network pharmacology inflammation |
| title | The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia |
| title_full | The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia |
| title_fullStr | The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia |
| title_full_unstemmed | The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia |
| title_short | The pharmacophylogenetic relationships of two edible medicinal plants in the genus Artemisia |
| title_sort | pharmacophylogenetic relationships of two edible medicinal plants in the genus artemisia |
| topic | Artemisia argyi Artemisia indica pharmaphylogeny metabolomics network pharmacology inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2022.949743/full |
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