How Can a Polymeric Formula Induce Remission in Crohn’s Disease Patients?
Crohn’s disease is an inflammatory bowel disease whose prevalence is increasing worldwide. Among medical strategies, dietary therapy with exclusive enteral nutrition is recommended as a first-line option, at least for children, because it induces clinical remission and mucosal healing. Modulen<su...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/8/4025 |
| _version_ | 1797537775599222784 |
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| author | Kawthar Boumessid Frederick Barreau Emmanuel Mas |
| author_facet | Kawthar Boumessid Frederick Barreau Emmanuel Mas |
| author_sort | Kawthar Boumessid |
| collection | DOAJ |
| description | Crohn’s disease is an inflammatory bowel disease whose prevalence is increasing worldwide. Among medical strategies, dietary therapy with exclusive enteral nutrition is recommended as a first-line option, at least for children, because it induces clinical remission and mucosal healing. Modulen<sup>®</sup>, a polymeric TGF-β2 enriched formula, has good palatability and is widely used. For the first time in the literature, this review outlines and discusses the clinical outcomes obtained with this therapy, as well as the potential mechanisms of action of its compounds. It can be explained by its TGF-β2 content, but also by its protein and lipid composition. Further well-designed studies are required to improve our knowledge and to optimize therapeutic strategies. |
| first_indexed | 2024-03-10T12:20:07Z |
| format | Article |
| id | doaj.art-3ffccfa97c5948fda540f853a400a743 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:20:07Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3ffccfa97c5948fda540f853a400a7432023-11-21T15:30:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01228402510.3390/ijms22084025How Can a Polymeric Formula Induce Remission in Crohn’s Disease Patients?Kawthar Boumessid0Frederick Barreau1Emmanuel Mas2INSERM, INRAE, ENVT, Université de Toulouse, UPS, F-31000 Toulouse, FranceINSERM, INRAE, ENVT, Université de Toulouse, UPS, F-31000 Toulouse, FranceINSERM, INRAE, ENVT, Université de Toulouse, UPS, F-31000 Toulouse, FranceCrohn’s disease is an inflammatory bowel disease whose prevalence is increasing worldwide. Among medical strategies, dietary therapy with exclusive enteral nutrition is recommended as a first-line option, at least for children, because it induces clinical remission and mucosal healing. Modulen<sup>®</sup>, a polymeric TGF-β2 enriched formula, has good palatability and is widely used. For the first time in the literature, this review outlines and discusses the clinical outcomes obtained with this therapy, as well as the potential mechanisms of action of its compounds. It can be explained by its TGF-β2 content, but also by its protein and lipid composition. Further well-designed studies are required to improve our knowledge and to optimize therapeutic strategies.https://www.mdpi.com/1422-0067/22/8/4025Crohn’s diseaseinflammatory bowel diseaseexclusive enteral nutritionmucosal healing |
| spellingShingle | Kawthar Boumessid Frederick Barreau Emmanuel Mas How Can a Polymeric Formula Induce Remission in Crohn’s Disease Patients? International Journal of Molecular Sciences Crohn’s disease inflammatory bowel disease exclusive enteral nutrition mucosal healing |
| title | How Can a Polymeric Formula Induce Remission in Crohn’s Disease Patients? |
| title_full | How Can a Polymeric Formula Induce Remission in Crohn’s Disease Patients? |
| title_fullStr | How Can a Polymeric Formula Induce Remission in Crohn’s Disease Patients? |
| title_full_unstemmed | How Can a Polymeric Formula Induce Remission in Crohn’s Disease Patients? |
| title_short | How Can a Polymeric Formula Induce Remission in Crohn’s Disease Patients? |
| title_sort | how can a polymeric formula induce remission in crohn s disease patients |
| topic | Crohn’s disease inflammatory bowel disease exclusive enteral nutrition mucosal healing |
| url | https://www.mdpi.com/1422-0067/22/8/4025 |
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