Safety Considerations for Humans and Other Vertebrates Regarding Agricultural Uses of Externally Applied RNA Molecules
The potential of double-stranded RNAs (dsRNAs) for use as topical biopesticides in agriculture was recently discussed during an OECD (Organisation for Economic Co-operation and Development) Conference on RNA interference (RNAi)-based pesticides. Several topics were presented and these covered differ...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpls.2020.00407/full |
| _version_ | 1818837730266710016 |
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| author | Thais B. Rodrigues Jay S. Petrick |
| author_facet | Thais B. Rodrigues Jay S. Petrick |
| author_sort | Thais B. Rodrigues |
| collection | DOAJ |
| description | The potential of double-stranded RNAs (dsRNAs) for use as topical biopesticides in agriculture was recently discussed during an OECD (Organisation for Economic Co-operation and Development) Conference on RNA interference (RNAi)-based pesticides. Several topics were presented and these covered different aspects of RNAi technology, its application, and its potential effects on target and non-target organisms (including both mammals and non-mammals). This review presents information relating to RNAi mechanisms in vertebrates, the history of safe RNA consumption, the biological barriers that contribute to the safety of its consumption, and effects related to humans and other vertebrates as discussed during the conference. We also review literature related to vertebrates exposed to RNA molecules and further consider human health safety assessments of RNAi-based biopesticides. This includes possible routes of exposure other than the ingestion of potential residual material in food and water (such as dermal and inhalation exposures during application in the field), the implications of different types of formulations and RNA structures, and the possibility of non-specific effects such as the activation of the innate immune system or saturation of the RNAi machinery. |
| first_indexed | 2024-12-19T03:27:09Z |
| format | Article |
| id | doaj.art-3ffe16c2f97f4afe8b6f40830ee187ec |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-19T03:27:09Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-3ffe16c2f97f4afe8b6f40830ee187ec2022-12-21T20:37:35ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2020-04-011110.3389/fpls.2020.00407507176Safety Considerations for Humans and Other Vertebrates Regarding Agricultural Uses of Externally Applied RNA MoleculesThais B. Rodrigues0Jay S. Petrick1GreenLight Biosciences, Inc., Medford, NC, United StatesBayer Crop Science, Chesterfield, MO, United StatesThe potential of double-stranded RNAs (dsRNAs) for use as topical biopesticides in agriculture was recently discussed during an OECD (Organisation for Economic Co-operation and Development) Conference on RNA interference (RNAi)-based pesticides. Several topics were presented and these covered different aspects of RNAi technology, its application, and its potential effects on target and non-target organisms (including both mammals and non-mammals). This review presents information relating to RNAi mechanisms in vertebrates, the history of safe RNA consumption, the biological barriers that contribute to the safety of its consumption, and effects related to humans and other vertebrates as discussed during the conference. We also review literature related to vertebrates exposed to RNA molecules and further consider human health safety assessments of RNAi-based biopesticides. This includes possible routes of exposure other than the ingestion of potential residual material in food and water (such as dermal and inhalation exposures during application in the field), the implications of different types of formulations and RNA structures, and the possibility of non-specific effects such as the activation of the innate immune system or saturation of the RNAi machinery.https://www.frontiersin.org/article/10.3389/fpls.2020.00407/fulldouble-stranded RNAbiopesticidehuman safetyRNA interferencesprayable dsRNA |
| spellingShingle | Thais B. Rodrigues Jay S. Petrick Safety Considerations for Humans and Other Vertebrates Regarding Agricultural Uses of Externally Applied RNA Molecules Frontiers in Plant Science double-stranded RNA biopesticide human safety RNA interference sprayable dsRNA |
| title | Safety Considerations for Humans and Other Vertebrates Regarding Agricultural Uses of Externally Applied RNA Molecules |
| title_full | Safety Considerations for Humans and Other Vertebrates Regarding Agricultural Uses of Externally Applied RNA Molecules |
| title_fullStr | Safety Considerations for Humans and Other Vertebrates Regarding Agricultural Uses of Externally Applied RNA Molecules |
| title_full_unstemmed | Safety Considerations for Humans and Other Vertebrates Regarding Agricultural Uses of Externally Applied RNA Molecules |
| title_short | Safety Considerations for Humans and Other Vertebrates Regarding Agricultural Uses of Externally Applied RNA Molecules |
| title_sort | safety considerations for humans and other vertebrates regarding agricultural uses of externally applied rna molecules |
| topic | double-stranded RNA biopesticide human safety RNA interference sprayable dsRNA |
| url | https://www.frontiersin.org/article/10.3389/fpls.2020.00407/full |
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