Diverse association between components of metabolic syndrome and chronic kidney disease in hypertension of different low-density lipoprotein cholesterol levels
Objectives: This study aimed to investigate the association between the metabolic syndrome (MetS) components and chronic kidney disease (CKD) in hypertension of different low-density lipoprotein cholesterol (LDL-C) levels. Methods: This national cross-sectional study was conducted in hospitals in 24...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2020-01-01
|
| Series: | Cardiology Plus |
| Subjects: | |
| Online Access: | http://www.cardiologyplus.org/article.asp?issn=2470-7511;year=2020;volume=5;issue=2;spage=89;epage=96;aulast=Bao |
| _version_ | 1828303321377538048 |
|---|---|
| author | Li-Wen Bao Kun Xie Li-Lian Bao Ying Shan Xin-Yu Zhuang Hai-Ming Shi Yong Li Xiu-Fang Gao for the UPPDATE collaboration |
| author_facet | Li-Wen Bao Kun Xie Li-Lian Bao Ying Shan Xin-Yu Zhuang Hai-Ming Shi Yong Li Xiu-Fang Gao for the UPPDATE collaboration |
| author_sort | Li-Wen Bao |
| collection | DOAJ |
| description | Objectives: This study aimed to investigate the association between the metabolic syndrome (MetS) components and chronic kidney disease (CKD) in hypertension of different low-density lipoprotein cholesterol (LDL-C) levels. Methods: This national cross-sectional study was conducted in hospitals in 24 cities of China and comprised of 4792 eligible hypertensive participants with a recorded creatinine level between 2017 and 2018. All participants underwent a clinical survey and clinical assessment and were required to provide biomedical reports within 1 year from their outpatient visit. Student's t-test, log-rank, and Chi-square tests and receiver operating characteristic curve (ROC) analysis were used in data analysis. Results: Participants' average age was 65.82 ± 12.74 years; 54.65% were male. Overall, 52.73%, 63.29%, 26.84%, and 77.27% of participants had a high waist circumference, elevated triglyceride (TG) level, low high-density lipoprotein cholesterol level, and impaired fasting glucose/diabetes, respectively. The adjusted odds ratio (OR) for CKD with MetS was 1.67 (95% confidence interval [CI] 1.32–2.10, P < 0.001). The risk of CKD was associated with older age (OR: 1.05, 95% CI: 1.04–1.06, P < 0.001), female (OR: 1.25, 95% CI: 1.01–1.55, P < 0.001), higher LDL-C level (OR: 1.17, 95% CI: 1.08–1.27, P = 0.03), higher TG level (OR: 1.38, 95% CI: 1.13–1.68, P = 0.001), impaired fasting glucose/diabetes (OR 1.48, 95% CI: 1.2–1.85, P < 0.001), and a combination of two or more than three MetS components (OR: 1.7, 95% CI: 1.07–2.71, P = 0.025; OR: 2.03, 95% CI: 1.08–3.13, P = 0.008, respectively) (ROC curve: 0.7). MetS remained significantly associated with CKD in both LDL-C subgroups, but different associations between the MetS components and CKD were found. Conclusions: MetS and its components are less associated with CKD of LDL-C <2.6 mmol/L than LDL-C ≥2.6 mmol/L in hypertension. LDL-C is significantly associated with CKD in hypertension of LDL-C level ≥2.6 mmol/L subgroup. |
| first_indexed | 2024-04-13T13:52:04Z |
| format | Article |
| id | doaj.art-3ffeb6336dc84a86a0f5629650e5bb21 |
| institution | Directory Open Access Journal |
| issn | 2470-7511 2470-752X |
| language | English |
| last_indexed | 2024-04-13T13:52:04Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Cardiology Plus |
| spelling | doaj.art-3ffeb6336dc84a86a0f5629650e5bb212022-12-22T02:44:19ZengWolters Kluwer Health/LWWCardiology Plus2470-75112470-752X2020-01-0152899610.4103/cp.cp_10_20Diverse association between components of metabolic syndrome and chronic kidney disease in hypertension of different low-density lipoprotein cholesterol levelsLi-Wen BaoKun XieLi-Lian BaoYing ShanXin-Yu ZhuangHai-Ming ShiYong LiXiu-Fang Gaofor the UPPDATE collaborationObjectives: This study aimed to investigate the association between the metabolic syndrome (MetS) components and chronic kidney disease (CKD) in hypertension of different low-density lipoprotein cholesterol (LDL-C) levels. Methods: This national cross-sectional study was conducted in hospitals in 24 cities of China and comprised of 4792 eligible hypertensive participants with a recorded creatinine level between 2017 and 2018. All participants underwent a clinical survey and clinical assessment and were required to provide biomedical reports within 1 year from their outpatient visit. Student's t-test, log-rank, and Chi-square tests and receiver operating characteristic curve (ROC) analysis were used in data analysis. Results: Participants' average age was 65.82 ± 12.74 years; 54.65% were male. Overall, 52.73%, 63.29%, 26.84%, and 77.27% of participants had a high waist circumference, elevated triglyceride (TG) level, low high-density lipoprotein cholesterol level, and impaired fasting glucose/diabetes, respectively. The adjusted odds ratio (OR) for CKD with MetS was 1.67 (95% confidence interval [CI] 1.32–2.10, P < 0.001). The risk of CKD was associated with older age (OR: 1.05, 95% CI: 1.04–1.06, P < 0.001), female (OR: 1.25, 95% CI: 1.01–1.55, P < 0.001), higher LDL-C level (OR: 1.17, 95% CI: 1.08–1.27, P = 0.03), higher TG level (OR: 1.38, 95% CI: 1.13–1.68, P = 0.001), impaired fasting glucose/diabetes (OR 1.48, 95% CI: 1.2–1.85, P < 0.001), and a combination of two or more than three MetS components (OR: 1.7, 95% CI: 1.07–2.71, P = 0.025; OR: 2.03, 95% CI: 1.08–3.13, P = 0.008, respectively) (ROC curve: 0.7). MetS remained significantly associated with CKD in both LDL-C subgroups, but different associations between the MetS components and CKD were found. Conclusions: MetS and its components are less associated with CKD of LDL-C <2.6 mmol/L than LDL-C ≥2.6 mmol/L in hypertension. LDL-C is significantly associated with CKD in hypertension of LDL-C level ≥2.6 mmol/L subgroup.http://www.cardiologyplus.org/article.asp?issn=2470-7511;year=2020;volume=5;issue=2;spage=89;epage=96;aulast=Baochronic kidney diseasehypertensionlow-density lipoprotein cholesterolmetabolic syndrome |
| spellingShingle | Li-Wen Bao Kun Xie Li-Lian Bao Ying Shan Xin-Yu Zhuang Hai-Ming Shi Yong Li Xiu-Fang Gao for the UPPDATE collaboration Diverse association between components of metabolic syndrome and chronic kidney disease in hypertension of different low-density lipoprotein cholesterol levels Cardiology Plus chronic kidney disease hypertension low-density lipoprotein cholesterol metabolic syndrome |
| title | Diverse association between components of metabolic syndrome and chronic kidney disease in hypertension of different low-density lipoprotein cholesterol levels |
| title_full | Diverse association between components of metabolic syndrome and chronic kidney disease in hypertension of different low-density lipoprotein cholesterol levels |
| title_fullStr | Diverse association between components of metabolic syndrome and chronic kidney disease in hypertension of different low-density lipoprotein cholesterol levels |
| title_full_unstemmed | Diverse association between components of metabolic syndrome and chronic kidney disease in hypertension of different low-density lipoprotein cholesterol levels |
| title_short | Diverse association between components of metabolic syndrome and chronic kidney disease in hypertension of different low-density lipoprotein cholesterol levels |
| title_sort | diverse association between components of metabolic syndrome and chronic kidney disease in hypertension of different low density lipoprotein cholesterol levels |
| topic | chronic kidney disease hypertension low-density lipoprotein cholesterol metabolic syndrome |
| url | http://www.cardiologyplus.org/article.asp?issn=2470-7511;year=2020;volume=5;issue=2;spage=89;epage=96;aulast=Bao |
| work_keys_str_mv | AT liwenbao diverseassociationbetweencomponentsofmetabolicsyndromeandchronickidneydiseaseinhypertensionofdifferentlowdensitylipoproteincholesterollevels AT kunxie diverseassociationbetweencomponentsofmetabolicsyndromeandchronickidneydiseaseinhypertensionofdifferentlowdensitylipoproteincholesterollevels AT lilianbao diverseassociationbetweencomponentsofmetabolicsyndromeandchronickidneydiseaseinhypertensionofdifferentlowdensitylipoproteincholesterollevels AT yingshan diverseassociationbetweencomponentsofmetabolicsyndromeandchronickidneydiseaseinhypertensionofdifferentlowdensitylipoproteincholesterollevels AT xinyuzhuang diverseassociationbetweencomponentsofmetabolicsyndromeandchronickidneydiseaseinhypertensionofdifferentlowdensitylipoproteincholesterollevels AT haimingshi diverseassociationbetweencomponentsofmetabolicsyndromeandchronickidneydiseaseinhypertensionofdifferentlowdensitylipoproteincholesterollevels AT yongli diverseassociationbetweencomponentsofmetabolicsyndromeandchronickidneydiseaseinhypertensionofdifferentlowdensitylipoproteincholesterollevels AT xiufanggao diverseassociationbetweencomponentsofmetabolicsyndromeandchronickidneydiseaseinhypertensionofdifferentlowdensitylipoproteincholesterollevels AT fortheuppdatecollaboration diverseassociationbetweencomponentsofmetabolicsyndromeandchronickidneydiseaseinhypertensionofdifferentlowdensitylipoproteincholesterollevels |