Effect of Carum carvi, a herbal bioenhancer on pharmacokinetics of antitubercular drugs: A study in healthy human volunteers
Aim and Objectives: The present study was undertaken in 20 healthy human volunteers to evaluate the effect of a herbal bioenhancer, Carum carvi on pharmacokinetics of rifampicin, isoniazid, and pyrazinamide in fixed dose combination (FDC). Materials and Methods: It was a prospective, two-period, ope...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Perspectives in Clinical Research |
| Subjects: | |
| Online Access: | http://www.picronline.org/article.asp?issn=2229-3485;year=2014;volume=5;issue=2;spage=80;epage=84;aulast=Choudhary |
| _version_ | 1828357047778803712 |
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| author | Naiyma Choudhary Vijay Khajuria Zahid H Gillani Vishal R Tandon Ekta Arora |
| author_facet | Naiyma Choudhary Vijay Khajuria Zahid H Gillani Vishal R Tandon Ekta Arora |
| author_sort | Naiyma Choudhary |
| collection | DOAJ |
| description | Aim and Objectives: The present study was undertaken in 20 healthy human volunteers to evaluate the effect of a herbal bioenhancer, Carum carvi on pharmacokinetics of rifampicin, isoniazid, and pyrazinamide in fixed dose combination (FDC). Materials and Methods: It was a prospective, two-period, open-label, cross-over experiment on 20 healthy human male volunteers. The volunteers were administered a single dose of FDC containing rifampicin (450 mg), isoniazid (300 mg), and pyrazinamide (1000 mg) and after 10 days washout period the same FDC along with C. carvi extract (100 mg) was administered. Blood samples were collected at different time-points and analyzed by high-performance liquid chromatography (HPLC). Detailed pharmacokinetic parameters were calculated, which included Cmax , area under curve (AUC), time to reach maximum plasma concentration (Tmax ), clearance (Cl), volume of distribution (Vd ), and half-life (t ½ ). Results: Additions of C. carvi extract lead to increase in plasma levels of rifampicin, isoniazid, and pyrazinamide. The bioavailability indices Cmax of rifampicin increased from 4.57 ± 0.19 to 5.95 ± 0.19 (P = 0.000) and AUC increased from 40.11 ± 1.69 to 53.01 ± 1.88 (P = 0.000). Similarly, Cmax of isoniazid increased from 2.66 ± 0.16 to 3.62 ± 0.16 (P = 0.000) and AUC from 17.72 ± 0.78 to 22.87 ± 0.94 (P = 0.000). The bioavailability indices of pyrazinamide also revealed an increase in Cmax from 18.81 ± 0.79 to 25.06 ± 1.14 (P = 0.000) and AUC from 107.65 ± 4.42 to 137.71 ± 5.92 (P = 0.000), respectively. Conclusion: C. carvi acts as a bioenhancer and modifies the kinetics of antitubercular treatment (ATT) favorably. |
| first_indexed | 2024-04-14T03:10:14Z |
| format | Article |
| id | doaj.art-3fff472c8896490b94ec322a7dc75975 |
| institution | Directory Open Access Journal |
| issn | 2229-3485 |
| language | English |
| last_indexed | 2024-04-14T03:10:14Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Perspectives in Clinical Research |
| spelling | doaj.art-3fff472c8896490b94ec322a7dc759752022-12-22T02:15:37ZengWolters Kluwer Medknow PublicationsPerspectives in Clinical Research2229-34852014-01-0152808410.4103/2229-3485.128027Effect of Carum carvi, a herbal bioenhancer on pharmacokinetics of antitubercular drugs: A study in healthy human volunteersNaiyma ChoudharyVijay KhajuriaZahid H GillaniVishal R TandonEkta AroraAim and Objectives: The present study was undertaken in 20 healthy human volunteers to evaluate the effect of a herbal bioenhancer, Carum carvi on pharmacokinetics of rifampicin, isoniazid, and pyrazinamide in fixed dose combination (FDC). Materials and Methods: It was a prospective, two-period, open-label, cross-over experiment on 20 healthy human male volunteers. The volunteers were administered a single dose of FDC containing rifampicin (450 mg), isoniazid (300 mg), and pyrazinamide (1000 mg) and after 10 days washout period the same FDC along with C. carvi extract (100 mg) was administered. Blood samples were collected at different time-points and analyzed by high-performance liquid chromatography (HPLC). Detailed pharmacokinetic parameters were calculated, which included Cmax , area under curve (AUC), time to reach maximum plasma concentration (Tmax ), clearance (Cl), volume of distribution (Vd ), and half-life (t ½ ). Results: Additions of C. carvi extract lead to increase in plasma levels of rifampicin, isoniazid, and pyrazinamide. The bioavailability indices Cmax of rifampicin increased from 4.57 ± 0.19 to 5.95 ± 0.19 (P = 0.000) and AUC increased from 40.11 ± 1.69 to 53.01 ± 1.88 (P = 0.000). Similarly, Cmax of isoniazid increased from 2.66 ± 0.16 to 3.62 ± 0.16 (P = 0.000) and AUC from 17.72 ± 0.78 to 22.87 ± 0.94 (P = 0.000). The bioavailability indices of pyrazinamide also revealed an increase in Cmax from 18.81 ± 0.79 to 25.06 ± 1.14 (P = 0.000) and AUC from 107.65 ± 4.42 to 137.71 ± 5.92 (P = 0.000), respectively. Conclusion: C. carvi acts as a bioenhancer and modifies the kinetics of antitubercular treatment (ATT) favorably.http://www.picronline.org/article.asp?issn=2229-3485;year=2014;volume=5;issue=2;spage=80;epage=84;aulast=ChoudharyBioavailabilitybioenhancerCarum carviisoniazidpyrazinamiderifampicintuberculosis |
| spellingShingle | Naiyma Choudhary Vijay Khajuria Zahid H Gillani Vishal R Tandon Ekta Arora Effect of Carum carvi, a herbal bioenhancer on pharmacokinetics of antitubercular drugs: A study in healthy human volunteers Perspectives in Clinical Research Bioavailability bioenhancer Carum carvi isoniazid pyrazinamide rifampicin tuberculosis |
| title | Effect of Carum carvi, a herbal bioenhancer on pharmacokinetics of antitubercular drugs: A study in healthy human volunteers |
| title_full | Effect of Carum carvi, a herbal bioenhancer on pharmacokinetics of antitubercular drugs: A study in healthy human volunteers |
| title_fullStr | Effect of Carum carvi, a herbal bioenhancer on pharmacokinetics of antitubercular drugs: A study in healthy human volunteers |
| title_full_unstemmed | Effect of Carum carvi, a herbal bioenhancer on pharmacokinetics of antitubercular drugs: A study in healthy human volunteers |
| title_short | Effect of Carum carvi, a herbal bioenhancer on pharmacokinetics of antitubercular drugs: A study in healthy human volunteers |
| title_sort | effect of carum carvi a herbal bioenhancer on pharmacokinetics of antitubercular drugs a study in healthy human volunteers |
| topic | Bioavailability bioenhancer Carum carvi isoniazid pyrazinamide rifampicin tuberculosis |
| url | http://www.picronline.org/article.asp?issn=2229-3485;year=2014;volume=5;issue=2;spage=80;epage=84;aulast=Choudhary |
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