In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions
Abstract In-vivo corneal confocal microscopy is a powerful imaging technique which provides clinicians and researcher with the capabilities to observe microstructures at the ocular surfaces in significant detail. In this Mini Review, the optics and image analysis methods with the use of corneal conf...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05005-8 |
| _version_ | 1797795506062098432 |
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| author | Jeremy Chung Bo Chiang Maitreyee Roy Juno Kim Maria Markoulli Arun V. Krishnan |
| author_facet | Jeremy Chung Bo Chiang Maitreyee Roy Juno Kim Maria Markoulli Arun V. Krishnan |
| author_sort | Jeremy Chung Bo Chiang |
| collection | DOAJ |
| description | Abstract In-vivo corneal confocal microscopy is a powerful imaging technique which provides clinicians and researcher with the capabilities to observe microstructures at the ocular surfaces in significant detail. In this Mini Review, the optics and image analysis methods with the use of corneal confocal microscopy are discussed. While novel insights of neuroanatomy and biology of the eyes, particularly the ocular surface, have been provided by corneal confocal microscopy, some debatable elements observed using this technique remain and these are explored in this Mini Review. Potential improvements in imaging methodology and instrumentation are also suggested. |
| first_indexed | 2024-03-13T03:18:59Z |
| format | Article |
| id | doaj.art-3fff9d33285f4f10804c61550d0b8582 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-13T03:18:59Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-3fff9d33285f4f10804c61550d0b85822023-06-25T11:25:09ZengNature PortfolioCommunications Biology2399-36422023-06-01611710.1038/s42003-023-05005-8In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directionsJeremy Chung Bo Chiang0Maitreyee Roy1Juno Kim2Maria Markoulli3Arun V. Krishnan4School of Optometry and Vision Science, Faculty of Medicine and Health, University of New South WalesSchool of Optometry and Vision Science, Faculty of Medicine and Health, University of New South WalesSchool of Optometry and Vision Science, Faculty of Medicine and Health, University of New South WalesSchool of Optometry and Vision Science, Faculty of Medicine and Health, University of New South WalesSchool of Clinical Medicine, University of New South WalesAbstract In-vivo corneal confocal microscopy is a powerful imaging technique which provides clinicians and researcher with the capabilities to observe microstructures at the ocular surfaces in significant detail. In this Mini Review, the optics and image analysis methods with the use of corneal confocal microscopy are discussed. While novel insights of neuroanatomy and biology of the eyes, particularly the ocular surface, have been provided by corneal confocal microscopy, some debatable elements observed using this technique remain and these are explored in this Mini Review. Potential improvements in imaging methodology and instrumentation are also suggested.https://doi.org/10.1038/s42003-023-05005-8 |
| spellingShingle | Jeremy Chung Bo Chiang Maitreyee Roy Juno Kim Maria Markoulli Arun V. Krishnan In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions Communications Biology |
| title | In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions |
| title_full | In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions |
| title_fullStr | In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions |
| title_full_unstemmed | In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions |
| title_short | In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions |
| title_sort | in vivo corneal confocal microscopy imaging analysis biological insights and future directions |
| url | https://doi.org/10.1038/s42003-023-05005-8 |
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