Indomethacin and Diclofenac Hybrids with Oleanolic Acid Oximes Modulate Key Signaling Pathways in Pancreatic Cancer Cells

Indomethacin and Diclofenac Hybrids with Oleanolic Acid Oximes Modulate Key Signaling Pathways in Pancreatic Cancer Cells

Our earlier studies showed that coupling nonsteroidal anti-inflammatory drugs (NSAIDs) with oleanolic acid derivatives increased their anti-inflammatory activity in human hepatoma cells. The aim of this study was to evaluate their effect on the signaling pathways involved in inflammation processes i...

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Bibliographic Details
Main Authors:	Maria Narożna, Violetta Krajka-Kuźniak, Robert Kleszcz, Wanda Baer-Dubowska
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Series:	International Journal of Molecular Sciences
Subjects:	diclofenac indomethacin oleanolic acid derivative conjugates NF-κB Nrf2 MAPKs
Online Access:	https://www.mdpi.com/1422-0067/23/3/1230

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