Cross-Talk and Subset Control of Microglia and Associated Myeloid Cells in Neurological Disorders
Neurological disorders are highly prevalent and often lead to chronic debilitating disease. Neuroinflammation is a major driver across the spectrum of disorders, and microglia are key mediators of this response, gaining wide acceptance as a druggable cell target. Moreover, clinical providers have li...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/21/3364 |
| _version_ | 1827646993819762688 |
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| author | Jatia Mills Liliana Ladner Eman Soliman John Leonard Paul D. Morton Michelle H. Theus |
| author_facet | Jatia Mills Liliana Ladner Eman Soliman John Leonard Paul D. Morton Michelle H. Theus |
| author_sort | Jatia Mills |
| collection | DOAJ |
| description | Neurological disorders are highly prevalent and often lead to chronic debilitating disease. Neuroinflammation is a major driver across the spectrum of disorders, and microglia are key mediators of this response, gaining wide acceptance as a druggable cell target. Moreover, clinical providers have limited ability to objectively quantify patient-specific changes in microglia status, which can be a predictor of illness and recovery. This necessitates the development of diagnostic biomarkers and imaging techniques to monitor microglia-mediated neuroinflammation in coordination with neurological outcomes. New insights into the polarization status of microglia have shed light on the regulation of disease progression and helped identify a modifiable target for therapeutics. Thus, the detection and monitoring of microglia activation through the inclusion of diagnostic biomarkers and imaging techniques will provide clinical tools to aid our understanding of the neurologic sequelae and improve long-term clinical care for patients. Recent achievements demonstrated by pre-clinical studies, using novel depletion and cell-targeted approaches as well as single-cell RNAseq, underscore the mechanistic players that coordinate microglial activation status and offer a future avenue for therapeutic intervention. |
| first_indexed | 2024-03-09T19:11:13Z |
| format | Article |
| id | doaj.art-40024302ae7942eca84128613438531d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T19:11:13Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-40024302ae7942eca84128613438531d2023-11-24T04:07:28ZengMDPI AGCells2073-44092022-10-011121336410.3390/cells11213364Cross-Talk and Subset Control of Microglia and Associated Myeloid Cells in Neurological DisordersJatia Mills0Liliana Ladner1Eman Soliman2John Leonard3Paul D. Morton4Michelle H. Theus5Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA 24061, USAVirginia Tech Carilion School of Medicine, Roanoke, VA 24016, USADepartment of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA 24061, USADepartment of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA 24061, USADepartment of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA 24061, USADepartment of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA 24061, USANeurological disorders are highly prevalent and often lead to chronic debilitating disease. Neuroinflammation is a major driver across the spectrum of disorders, and microglia are key mediators of this response, gaining wide acceptance as a druggable cell target. Moreover, clinical providers have limited ability to objectively quantify patient-specific changes in microglia status, which can be a predictor of illness and recovery. This necessitates the development of diagnostic biomarkers and imaging techniques to monitor microglia-mediated neuroinflammation in coordination with neurological outcomes. New insights into the polarization status of microglia have shed light on the regulation of disease progression and helped identify a modifiable target for therapeutics. Thus, the detection and monitoring of microglia activation through the inclusion of diagnostic biomarkers and imaging techniques will provide clinical tools to aid our understanding of the neurologic sequelae and improve long-term clinical care for patients. Recent achievements demonstrated by pre-clinical studies, using novel depletion and cell-targeted approaches as well as single-cell RNAseq, underscore the mechanistic players that coordinate microglial activation status and offer a future avenue for therapeutic intervention.https://www.mdpi.com/2073-4409/11/21/3364single-cell sequencingcirculating monocytesmacrophagesneuroinflammationneurological diseasebone marrow transplant |
| spellingShingle | Jatia Mills Liliana Ladner Eman Soliman John Leonard Paul D. Morton Michelle H. Theus Cross-Talk and Subset Control of Microglia and Associated Myeloid Cells in Neurological Disorders Cells single-cell sequencing circulating monocytes macrophages neuroinflammation neurological disease bone marrow transplant |
| title | Cross-Talk and Subset Control of Microglia and Associated Myeloid Cells in Neurological Disorders |
| title_full | Cross-Talk and Subset Control of Microglia and Associated Myeloid Cells in Neurological Disorders |
| title_fullStr | Cross-Talk and Subset Control of Microglia and Associated Myeloid Cells in Neurological Disorders |
| title_full_unstemmed | Cross-Talk and Subset Control of Microglia and Associated Myeloid Cells in Neurological Disorders |
| title_short | Cross-Talk and Subset Control of Microglia and Associated Myeloid Cells in Neurological Disorders |
| title_sort | cross talk and subset control of microglia and associated myeloid cells in neurological disorders |
| topic | single-cell sequencing circulating monocytes macrophages neuroinflammation neurological disease bone marrow transplant |
| url | https://www.mdpi.com/2073-4409/11/21/3364 |
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