The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome

The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome

ObjectiveTwo missense mutations in KCNQ1, an imprinted gene that encodes the alpha subunit of the voltage-gated potassium channel Kv7.1, cause autosomal dominant growth hormone deficiency and maternally inherited gingival fibromatosis. We evaluated endocrine features, birth size, and subsequent soma...

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Bibliographic Details
Main Authors: Heta Huttunen, Matti Hero, Mitja Lääperi, Johanna Känsäkoski, Heikki Swan, Joel A. Hirsch, Päivi J. Miettinen, Taneli Raivio
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Endocrinology
Subjects:
growth
ion channels
KCNQ1
long QT syndrome 1
beta blocker
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2018.00194/full

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