Exploring the bidirectional causal link between household income status and genetic susceptibility to neurological diseases: findings from a Mendelian randomization study
ObjectivesObservational studies have revealed that socioeconomic status is associated with neurological disorders and aging. However, the potential causal effect between the two remains unclear. We therefore aimed to investigate the causal relationship between household income status and genetic sus...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1202747/full |
| _version_ | 1797772165885460480 |
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| author | Weidong Nong Gui Mo Chun Luo |
| author_facet | Weidong Nong Gui Mo Chun Luo |
| author_sort | Weidong Nong |
| collection | DOAJ |
| description | ObjectivesObservational studies have revealed that socioeconomic status is associated with neurological disorders and aging. However, the potential causal effect between the two remains unclear. We therefore aimed to investigate the causal relationship between household income status and genetic susceptibility to neurological diseases using a bidirectional Mendelian randomization (MR) study.MethodsAn MR study was conducted on a large-sample cohort of the European population pulled from a publicly available genome-wide association study dataset, using a random-effects inverse-variance weighting model as the main standard. MR-Egger regression, weighted median, and maximum likelihood estimation were also performed concurrently as supplements. A sensitivity analysis, consisting of a heterogeneity test and horizontal pleiotropy test, was performed using Cochran’s Q, MR-Egger intercept, and MR-PRESSO tests to ensure the reliability of the conclusion.ResultsThe results suggested that higher household income tended to lower the risk of genetic susceptibility to Alzheimer’s disease (odds ratio [OR]: 0.740, 95% confidence interval [CI] = 0.559–0.980, p-value = 0.036) and ischemic stroke (OR: 0.801, 95% CI = 0.662–0.968, p-value = 0.022). By contrast, higher household income tended to increase the risk of genetic susceptibility to Parkinson’s disease (OR: 2.605, 95% CI = 1.413–4.802, p-value = 0.002). No associations were evident for intracranial hemorrhage (OR: 1.002, 95% CI = 0.607–1.653, p-value = 0.993), cerebral aneurysm (OR: 0.597, 95% CI = 0.243–1.465, p-value = 0.260), subarachnoid hemorrhage (OR: 1.474, 95% CI = 0.699–3.110, p-value = 0.308), or epilepsy (OR: 1.029, 95% CI = 0.662–1.600, p-value = 0.899). The reverse MR study suggested no reverse causal relationship between neurological disorders and household income status. A sensitivity analysis verified the reliability of the results.ConclusionOur results revealed that the populations with a superior household income exhibit an increased predisposition of genetic susceptibility to Parkinson’s Disease, while demonstrating a potential decreased genetic susceptibility to ischemic stroke and Alzheimer’s disease. |
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| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-12T21:48:05Z |
| publishDate | 2023-07-01 |
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| spelling | doaj.art-4003d1130b274c46b156742b32a4f8bc2023-07-26T07:27:29ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-07-011110.3389/fpubh.2023.12027471202747Exploring the bidirectional causal link between household income status and genetic susceptibility to neurological diseases: findings from a Mendelian randomization studyWeidong NongGui MoChun LuoObjectivesObservational studies have revealed that socioeconomic status is associated with neurological disorders and aging. However, the potential causal effect between the two remains unclear. We therefore aimed to investigate the causal relationship between household income status and genetic susceptibility to neurological diseases using a bidirectional Mendelian randomization (MR) study.MethodsAn MR study was conducted on a large-sample cohort of the European population pulled from a publicly available genome-wide association study dataset, using a random-effects inverse-variance weighting model as the main standard. MR-Egger regression, weighted median, and maximum likelihood estimation were also performed concurrently as supplements. A sensitivity analysis, consisting of a heterogeneity test and horizontal pleiotropy test, was performed using Cochran’s Q, MR-Egger intercept, and MR-PRESSO tests to ensure the reliability of the conclusion.ResultsThe results suggested that higher household income tended to lower the risk of genetic susceptibility to Alzheimer’s disease (odds ratio [OR]: 0.740, 95% confidence interval [CI] = 0.559–0.980, p-value = 0.036) and ischemic stroke (OR: 0.801, 95% CI = 0.662–0.968, p-value = 0.022). By contrast, higher household income tended to increase the risk of genetic susceptibility to Parkinson’s disease (OR: 2.605, 95% CI = 1.413–4.802, p-value = 0.002). No associations were evident for intracranial hemorrhage (OR: 1.002, 95% CI = 0.607–1.653, p-value = 0.993), cerebral aneurysm (OR: 0.597, 95% CI = 0.243–1.465, p-value = 0.260), subarachnoid hemorrhage (OR: 1.474, 95% CI = 0.699–3.110, p-value = 0.308), or epilepsy (OR: 1.029, 95% CI = 0.662–1.600, p-value = 0.899). The reverse MR study suggested no reverse causal relationship between neurological disorders and household income status. A sensitivity analysis verified the reliability of the results.ConclusionOur results revealed that the populations with a superior household income exhibit an increased predisposition of genetic susceptibility to Parkinson’s Disease, while demonstrating a potential decreased genetic susceptibility to ischemic stroke and Alzheimer’s disease.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1202747/fullhousehold income statusneurological diseasescausal relationshipinstrumental variableMendelian randomization study |
| spellingShingle | Weidong Nong Gui Mo Chun Luo Exploring the bidirectional causal link between household income status and genetic susceptibility to neurological diseases: findings from a Mendelian randomization study Frontiers in Public Health household income status neurological diseases causal relationship instrumental variable Mendelian randomization study |
| title | Exploring the bidirectional causal link between household income status and genetic susceptibility to neurological diseases: findings from a Mendelian randomization study |
| title_full | Exploring the bidirectional causal link between household income status and genetic susceptibility to neurological diseases: findings from a Mendelian randomization study |
| title_fullStr | Exploring the bidirectional causal link between household income status and genetic susceptibility to neurological diseases: findings from a Mendelian randomization study |
| title_full_unstemmed | Exploring the bidirectional causal link between household income status and genetic susceptibility to neurological diseases: findings from a Mendelian randomization study |
| title_short | Exploring the bidirectional causal link between household income status and genetic susceptibility to neurological diseases: findings from a Mendelian randomization study |
| title_sort | exploring the bidirectional causal link between household income status and genetic susceptibility to neurological diseases findings from a mendelian randomization study |
| topic | household income status neurological diseases causal relationship instrumental variable Mendelian randomization study |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1202747/full |
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