Symptom-severity-related brain connectivity alterations in functional movement disorders
Background: Functional movement disorders, a common cause of neurological disabilities, can occur with heterogeneous motor manifestations including functional weakness. However, the underlying mechanisms related to brain function and connectivity are unknown. Objective: To identify brain connectivit...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222000468 |
| _version_ | 1818009143235051520 |
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| author | Karsten Mueller Filip Růžička Matěj Slovák Zuzana Forejtová Petr Dušek Pavel Dušek Robert Jech Tereza Serranová |
| author_facet | Karsten Mueller Filip Růžička Matěj Slovák Zuzana Forejtová Petr Dušek Pavel Dušek Robert Jech Tereza Serranová |
| author_sort | Karsten Mueller |
| collection | DOAJ |
| description | Background: Functional movement disorders, a common cause of neurological disabilities, can occur with heterogeneous motor manifestations including functional weakness. However, the underlying mechanisms related to brain function and connectivity are unknown. Objective: To identify brain connectivity alterations related to functional weakness we assessed network centrality changes in a group of patients with heterogeneous motor manifestations using task-free functional MRI in combination with different network centrality approaches. Methods: Task-free functional MRI was performed in 48 patients with heterogeneous motor manifestations including 28 patients showing functional weakness and 65 age- and sex-matched healthy controls. Functional connectivity differences were assessed using different network centrality approaches, i.e. global correlation, eigenvector centrality, and intrinsic connectivity. Motor symptom severity was assessed using The Simplified Functional Movement Disorders Rating Scale and correlated with network centrality. Results: Comparing patients with and without functional weakness showed significant network centrality differences in the left temporoparietal junction and precuneus. Patients with functional weakness showed increased centrality in the same anatomical regions when comparing functional weakness with healthy controls. Moreover, in the same regions, patients with functional weakness showed a positive correlation between motor symptom severity and network centrality. This correlation was shown to be specific to functional weakness with an interaction analysis, confirming a significant difference between patients with and without functional weakness. Conclusions: We identified the temporoparietal junction and precuneus as key regions involved in brain connectivity alterations related to functional weakness. We propose that both regions may be promising targets for phenotype-specific non-invasive brain stimulation. |
| first_indexed | 2024-04-14T05:39:08Z |
| format | Article |
| id | doaj.art-40045f2b674a41109298dabebd3a8604 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-14T05:39:08Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-40045f2b674a41109298dabebd3a86042022-12-22T02:09:31ZengElsevierNeuroImage: Clinical2213-15822022-01-0134102981Symptom-severity-related brain connectivity alterations in functional movement disordersKarsten Mueller0Filip Růžička1Matěj Slovák2Zuzana Forejtová3Petr Dušek4Pavel Dušek5Robert Jech6Tereza Serranová7Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Corresponding authors at: Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstr 1A, 04103 Leipzig, Germany (Karsten Mueller). Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Kateřinská 30, 120 00 Praha, Czech Republic (Tereza Serranová).Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech RepublicDepartment of Neurology and Center of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech RepublicDepartment of Neurology and Center of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech RepublicDepartment of Neurology and Center of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech RepublicDepartment of Neurology and Center of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech RepublicDepartment of Neurology and Center of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech RepublicDepartment of Neurology and Center of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Czech Republic; Corresponding authors at: Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstr 1A, 04103 Leipzig, Germany (Karsten Mueller). Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, First Faculty of Medicine and General University Hospital in Prague, Kateřinská 30, 120 00 Praha, Czech Republic (Tereza Serranová).Background: Functional movement disorders, a common cause of neurological disabilities, can occur with heterogeneous motor manifestations including functional weakness. However, the underlying mechanisms related to brain function and connectivity are unknown. Objective: To identify brain connectivity alterations related to functional weakness we assessed network centrality changes in a group of patients with heterogeneous motor manifestations using task-free functional MRI in combination with different network centrality approaches. Methods: Task-free functional MRI was performed in 48 patients with heterogeneous motor manifestations including 28 patients showing functional weakness and 65 age- and sex-matched healthy controls. Functional connectivity differences were assessed using different network centrality approaches, i.e. global correlation, eigenvector centrality, and intrinsic connectivity. Motor symptom severity was assessed using The Simplified Functional Movement Disorders Rating Scale and correlated with network centrality. Results: Comparing patients with and without functional weakness showed significant network centrality differences in the left temporoparietal junction and precuneus. Patients with functional weakness showed increased centrality in the same anatomical regions when comparing functional weakness with healthy controls. Moreover, in the same regions, patients with functional weakness showed a positive correlation between motor symptom severity and network centrality. This correlation was shown to be specific to functional weakness with an interaction analysis, confirming a significant difference between patients with and without functional weakness. Conclusions: We identified the temporoparietal junction and precuneus as key regions involved in brain connectivity alterations related to functional weakness. We propose that both regions may be promising targets for phenotype-specific non-invasive brain stimulation.http://www.sciencedirect.com/science/article/pii/S2213158222000468Functional movement disordersMotor conversion disorderFunctional weaknessBrain connectivityFunctional connectivityFunctional magnetic resonance imaging |
| spellingShingle | Karsten Mueller Filip Růžička Matěj Slovák Zuzana Forejtová Petr Dušek Pavel Dušek Robert Jech Tereza Serranová Symptom-severity-related brain connectivity alterations in functional movement disorders NeuroImage: Clinical Functional movement disorders Motor conversion disorder Functional weakness Brain connectivity Functional connectivity Functional magnetic resonance imaging |
| title | Symptom-severity-related brain connectivity alterations in functional movement disorders |
| title_full | Symptom-severity-related brain connectivity alterations in functional movement disorders |
| title_fullStr | Symptom-severity-related brain connectivity alterations in functional movement disorders |
| title_full_unstemmed | Symptom-severity-related brain connectivity alterations in functional movement disorders |
| title_short | Symptom-severity-related brain connectivity alterations in functional movement disorders |
| title_sort | symptom severity related brain connectivity alterations in functional movement disorders |
| topic | Functional movement disorders Motor conversion disorder Functional weakness Brain connectivity Functional connectivity Functional magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222000468 |
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