Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat.
Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers. A renewed sense of urgency is required as obesity remains an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396420301997 |
| _version_ | 1818522646002794496 |
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| author | David R. Rawnsley Abhinav Diwan |
| author_facet | David R. Rawnsley Abhinav Diwan |
| author_sort | David R. Rawnsley |
| collection | DOAJ |
| description | Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers. A renewed sense of urgency is required as obesity remains an intractable problem, despite a rapidly expanding armamentarium of behavioral, pharmacologic and surgical approaches which fall short of delivering sustained results |
| first_indexed | 2024-12-11T05:36:02Z |
| format | Article |
| id | doaj.art-4004c46adaae4104a3bf297c742834af |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-11T05:36:02Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-4004c46adaae4104a3bf297c742834af2022-12-22T01:19:17ZengElsevierEBioMedicine2352-39642020-06-0156102824Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat.David R. Rawnsley0Abhinav Diwan1Cardiolovascular Division, Washington University School of Medicine, Division of Cardiology, 660 S. Euclid, CSRB 827 NTA, St. Louis, MO 63110, United States; Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, United StatesCardiolovascular Division, Washington University School of Medicine, Division of Cardiology, 660 S. Euclid, CSRB 827 NTA, St. Louis, MO 63110, United States; Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, United States; John Cochran Veterans Affairs Medical Center, St. Louis, MO, United States; Corresponding author.Obesity is a global epidemic contributing to the rising prevalence of multiple disorders including metabolic syndrome, diabetes, fatty liver disease, cardiovascular and cerebrovascular disease, Alzheimer's disease and certain cancers. A renewed sense of urgency is required as obesity remains an intractable problem, despite a rapidly expanding armamentarium of behavioral, pharmacologic and surgical approaches which fall short of delivering sustained resultshttp://www.sciencedirect.com/science/article/pii/S2352396420301997ObesityCD36LysosomePre-adipocytes |
| spellingShingle | David R. Rawnsley Abhinav Diwan Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat. EBioMedicine Obesity CD36 Lysosome Pre-adipocytes |
| title | Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat. |
| title_full | Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat. |
| title_fullStr | Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat. |
| title_full_unstemmed | Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat. |
| title_short | Lysosome impairment as a trigger for inflammation in obesity: The proof is in the fat. |
| title_sort | lysosome impairment as a trigger for inflammation in obesity the proof is in the fat |
| topic | Obesity CD36 Lysosome Pre-adipocytes |
| url | http://www.sciencedirect.com/science/article/pii/S2352396420301997 |
| work_keys_str_mv | AT davidrrawnsley lysosomeimpairmentasatriggerforinflammationinobesitytheproofisinthefat AT abhinavdiwan lysosomeimpairmentasatriggerforinflammationinobesitytheproofisinthefat |