The role of interleukin-1ß and interleukin-33 in atopic dermatitis
Introduction: Interleukin-1 super family is a group of cytokines that play a role in the regulation of immune and inflammatory responses. Interleukin-33 is a member of this family and is known to induce expression of the T helper2 cytokines that are important players in atopic dermatitis. Aim: To ev...
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| Format: | Article |
| Language: | English |
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Our Dermatology Online
2013-01-01
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| Series: | Nasza Dermatologia Online |
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| Online Access: | http://www.odermatol.com/issue-in-html/2013-1-2-interleukin/ |
| _version_ | 1811268286683283456 |
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| author | Rania M. Abdel Hay Noha F. Ibrahim Dina Metwally Laila A. Rashed |
| author_facet | Rania M. Abdel Hay Noha F. Ibrahim Dina Metwally Laila A. Rashed |
| author_sort | Rania M. Abdel Hay |
| collection | DOAJ |
| description | Introduction: Interleukin-1 super family is a group of cytokines that play a role in the regulation of immune and inflammatory responses. Interleukin-33 is a member of this family and is known to induce expression of the T helper2 cytokines that are important players in atopic dermatitis. Aim: To evaluate the expression of interleukins-1ß and 33 as T helper2 cytokines inducers in patients with atopic dermatitis. Materials andMethods: This study included 20 atopic patients and 20 apparently healthy individuals serving as controls. Skin biopsies from all participants will be examined for detection of interleukins-1ß and 33 by ELISA technique.Results: Both interleukins were statistically higher (P<0.001) in patients than in controls. A statistically significant (P=0.011) highest levels of interleukin-33 was detected in severe cases of atopics when compared to mild and moderate cases. A significant correlation (r=0.632, P=0.003) between both interleukins was detected in atopics.Conclusions: This is the first study to evaluate both interleukin-1ß and33 together in atopic patients. Both interleukins could play a role in the recruitment of lymphocytes during the inflammatory reaction in atopic dermatitis and could be targeted in the treatment of resistant cases. |
| first_indexed | 2024-04-12T21:20:13Z |
| format | Article |
| id | doaj.art-40063cd815ee4121a6cc83054048a40f |
| institution | Directory Open Access Journal |
| issn | 2081-9390 |
| language | English |
| last_indexed | 2024-04-12T21:20:13Z |
| publishDate | 2013-01-01 |
| publisher | Our Dermatology Online |
| record_format | Article |
| series | Nasza Dermatologia Online |
| spelling | doaj.art-40063cd815ee4121a6cc83054048a40f2022-12-22T03:16:20ZengOur Dermatology OnlineNasza Dermatologia Online2081-93902013-01-01411114The role of interleukin-1ß and interleukin-33 in atopic dermatitisRania M. Abdel HayNoha F. IbrahimDina MetwallyLaila A. RashedIntroduction: Interleukin-1 super family is a group of cytokines that play a role in the regulation of immune and inflammatory responses. Interleukin-33 is a member of this family and is known to induce expression of the T helper2 cytokines that are important players in atopic dermatitis. Aim: To evaluate the expression of interleukins-1ß and 33 as T helper2 cytokines inducers in patients with atopic dermatitis. Materials andMethods: This study included 20 atopic patients and 20 apparently healthy individuals serving as controls. Skin biopsies from all participants will be examined for detection of interleukins-1ß and 33 by ELISA technique.Results: Both interleukins were statistically higher (P<0.001) in patients than in controls. A statistically significant (P=0.011) highest levels of interleukin-33 was detected in severe cases of atopics when compared to mild and moderate cases. A significant correlation (r=0.632, P=0.003) between both interleukins was detected in atopics.Conclusions: This is the first study to evaluate both interleukin-1ß and33 together in atopic patients. Both interleukins could play a role in the recruitment of lymphocytes during the inflammatory reaction in atopic dermatitis and could be targeted in the treatment of resistant cases.http://www.odermatol.com/issue-in-html/2013-1-2-interleukin/atopic dermatitisInterleukin-1ßInterleukin-33 |
| spellingShingle | Rania M. Abdel Hay Noha F. Ibrahim Dina Metwally Laila A. Rashed The role of interleukin-1ß and interleukin-33 in atopic dermatitis Nasza Dermatologia Online atopic dermatitis Interleukin-1ß Interleukin-33 |
| title | The role of interleukin-1ß and interleukin-33 in atopic dermatitis |
| title_full | The role of interleukin-1ß and interleukin-33 in atopic dermatitis |
| title_fullStr | The role of interleukin-1ß and interleukin-33 in atopic dermatitis |
| title_full_unstemmed | The role of interleukin-1ß and interleukin-33 in atopic dermatitis |
| title_short | The role of interleukin-1ß and interleukin-33 in atopic dermatitis |
| title_sort | role of interleukin 1ss and interleukin 33 in atopic dermatitis |
| topic | atopic dermatitis Interleukin-1ß Interleukin-33 |
| url | http://www.odermatol.com/issue-in-html/2013-1-2-interleukin/ |
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