Inhibition of IRE1 modifies hypoxic regulation of G6PD, GPI, TKT, TALDO1, PGLS and RPIA genes expression in U87 glioma cells

Inhibition of IRE1 modifies hypoxic regulation of G6PD, GPI, TKT, TALDO1, PGLS and RPIA genes expression in U87 glioma cells

We have studied the effect of hypoxia on the expression level of mRNA of the basic enzymes of pentose-phosphate cycle (G6PD, TKT, TALDO1, PGLS and RPIA) and glucose-6-phosphate isomerase (GPI) in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme 1). It was shown that hypo...

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Bibliographic Details
Main Authors: O. H. Minchenko, I. A. Garmash, D. O. Minchenko, A. Y. Kuznetsova, O. O. Ratushna
Format: Article
Language:English
Published: National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 2017-02-01
Series:The Ukrainian Biochemical Journal
Subjects:
G6PD
IRE1 inhibition
GPI
hypoxia
Online Access:http://ukrbiochemjournal.org/wp-content/uploads/2017/01/Minchenko_1_17.pdf

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