Evaluation of liver regeneration with use of diet supplemented with l-arginine
PURPOSE:To compare controlled liver regeneration in rats submitted to 60% hepatic resection having L-arginine supplemented diet, based on weight changes of the regenerated liver, laboratory parameters of liver function and pathological findings.METHODS:Thirty-six rats were divided into two groups, c...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2014-09-01
|
| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900603&tlng=en |
| _version_ | 1819105890973777920 |
|---|---|
| author | Widlani Sousa Montenegro Osvaldo Malafaia Paulo Afonso Nunes Nassif Luciane Bugmann Moreira Manoel Alberto Prestes Márcio Hiroaki Kume Leandro Bressianini Jurkonis Igor Furlan Cella |
| author_facet | Widlani Sousa Montenegro Osvaldo Malafaia Paulo Afonso Nunes Nassif Luciane Bugmann Moreira Manoel Alberto Prestes Márcio Hiroaki Kume Leandro Bressianini Jurkonis Igor Furlan Cella |
| author_sort | Widlani Sousa Montenegro |
| collection | DOAJ |
| description | PURPOSE:To compare controlled liver regeneration in rats submitted to 60% hepatic resection having L-arginine supplemented diet, based on weight changes of the regenerated liver, laboratory parameters of liver function and pathological findings.METHODS:Thirty-six rats were divided into two groups, control and L- arginine. The first received standard chow and saline solution by gavage. The second had supplementation with L- arginine. Animals were killed on postoperative period at 24h, 72h and seven days. For analysis of liver regeneration was used Kwon formula for weight, laboratory tests and mitosis.RESULTS: Weight, showed no benefit with L- arginine supplementation; however, intergroup comparison in the first 24h observed positive effect on supplementation (p=0.008). Alkaline phosphatase was increased in arginine group (p<0.04). The number of mitoses showed no difference between the two groups; however, in the first 24 hours, the supplemented group had higher number of mitoses within the groups (p=0.03).CONCLUSION:Supplementation with L-arginine did not show benefits in liver regeneration; however, supplemented group in the first 24 hours showed benefits over 72 hours and seven days of the evaluation by weight gain and number of mitosis. |
| first_indexed | 2024-12-22T02:29:27Z |
| format | Article |
| id | doaj.art-4006eb55b5e34f149b46b8de4f9a9c9c |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-22T02:29:27Z |
| publishDate | 2014-09-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-4006eb55b5e34f149b46b8de4f9a9c9c2022-12-21T18:41:55ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502014-09-0129960360710.1590/S0102-8650201400150008Evaluation of liver regeneration with use of diet supplemented with l-arginineWidlani Sousa MontenegroOsvaldo MalafaiaPaulo Afonso Nunes NassifLuciane Bugmann MoreiraManoel Alberto PrestesMárcio Hiroaki KumeLeandro Bressianini JurkonisIgor Furlan CellaPURPOSE:To compare controlled liver regeneration in rats submitted to 60% hepatic resection having L-arginine supplemented diet, based on weight changes of the regenerated liver, laboratory parameters of liver function and pathological findings.METHODS:Thirty-six rats were divided into two groups, control and L- arginine. The first received standard chow and saline solution by gavage. The second had supplementation with L- arginine. Animals were killed on postoperative period at 24h, 72h and seven days. For analysis of liver regeneration was used Kwon formula for weight, laboratory tests and mitosis.RESULTS: Weight, showed no benefit with L- arginine supplementation; however, intergroup comparison in the first 24h observed positive effect on supplementation (p=0.008). Alkaline phosphatase was increased in arginine group (p<0.04). The number of mitoses showed no difference between the two groups; however, in the first 24 hours, the supplemented group had higher number of mitoses within the groups (p=0.03).CONCLUSION:Supplementation with L-arginine did not show benefits in liver regeneration; however, supplemented group in the first 24 hours showed benefits over 72 hours and seven days of the evaluation by weight gain and number of mitosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900603&tlng=enArginineLiver RegenerationHepatectomyRats |
| spellingShingle | Widlani Sousa Montenegro Osvaldo Malafaia Paulo Afonso Nunes Nassif Luciane Bugmann Moreira Manoel Alberto Prestes Márcio Hiroaki Kume Leandro Bressianini Jurkonis Igor Furlan Cella Evaluation of liver regeneration with use of diet supplemented with l-arginine Acta Cirúrgica Brasileira Arginine Liver Regeneration Hepatectomy Rats |
| title | Evaluation of liver regeneration with use of diet supplemented with l-arginine |
| title_full | Evaluation of liver regeneration with use of diet supplemented with l-arginine |
| title_fullStr | Evaluation of liver regeneration with use of diet supplemented with l-arginine |
| title_full_unstemmed | Evaluation of liver regeneration with use of diet supplemented with l-arginine |
| title_short | Evaluation of liver regeneration with use of diet supplemented with l-arginine |
| title_sort | evaluation of liver regeneration with use of diet supplemented with l arginine |
| topic | Arginine Liver Regeneration Hepatectomy Rats |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000900603&tlng=en |
| work_keys_str_mv | AT widlanisousamontenegro evaluationofliverregenerationwithuseofdietsupplementedwithlarginine AT osvaldomalafaia evaluationofliverregenerationwithuseofdietsupplementedwithlarginine AT pauloafonsonunesnassif evaluationofliverregenerationwithuseofdietsupplementedwithlarginine AT lucianebugmannmoreira evaluationofliverregenerationwithuseofdietsupplementedwithlarginine AT manoelalbertoprestes evaluationofliverregenerationwithuseofdietsupplementedwithlarginine AT marciohiroakikume evaluationofliverregenerationwithuseofdietsupplementedwithlarginine AT leandrobressianinijurkonis evaluationofliverregenerationwithuseofdietsupplementedwithlarginine AT igorfurlancella evaluationofliverregenerationwithuseofdietsupplementedwithlarginine |