Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1
The nonreceptor tyrosine kinase (NRTK) Ack1 comprises a distinct arrangement of non-catalytic modules. Its SH3 domain has a C-terminal to the kinase domain (SH1), in contrast to the typical SH3-SH2-SH1 layout in NRTKs. The Ack1 is the only protein that shares a region of high homology to the tumor s...
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MDPI AG
2023-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/6/900 |
| _version_ | 1797612828458221568 |
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| author | Yagmur Kan YiTing Paung Markus A. Seeliger W. Todd Miller |
| author_facet | Yagmur Kan YiTing Paung Markus A. Seeliger W. Todd Miller |
| author_sort | Yagmur Kan |
| collection | DOAJ |
| description | The nonreceptor tyrosine kinase (NRTK) Ack1 comprises a distinct arrangement of non-catalytic modules. Its SH3 domain has a C-terminal to the kinase domain (SH1), in contrast to the typical SH3-SH2-SH1 layout in NRTKs. The Ack1 is the only protein that shares a region of high homology to the tumor suppressor protein Mig6, a modulator of EGFR. The vertebrate Acks make up the only tyrosine kinase (TK) family known to carry a UBA domain. The GTPase binding and SAM domains are also uncommon in the NRTKs. In addition to being a downstream effector of receptor tyrosine kinases (RTKs) and integrins, Ack1 can act as an epigenetic regulator, modulate the degradation of the epidermal growth factor receptor (EGFR), confer drug resistance, and mediate the progression of hormone-sensitive tumors. In this review, we discuss the domain architecture of Ack1 in relation to other protein kinases that possess such defined regulatory domains. |
| first_indexed | 2024-03-11T06:47:30Z |
| format | Article |
| id | doaj.art-4007c92046694eb7aee38ca451c20fbe |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T06:47:30Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4007c92046694eb7aee38ca451c20fbe2023-11-17T10:13:26ZengMDPI AGCells2073-44092023-03-0112690010.3390/cells12060900Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1Yagmur Kan0YiTing Paung1Markus A. Seeliger2W. Todd Miller3Department of Physiology and Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USADepartment of Pharmacology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USADepartment of Pharmacology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USADepartment of Physiology and Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY 11794-8661, USAThe nonreceptor tyrosine kinase (NRTK) Ack1 comprises a distinct arrangement of non-catalytic modules. Its SH3 domain has a C-terminal to the kinase domain (SH1), in contrast to the typical SH3-SH2-SH1 layout in NRTKs. The Ack1 is the only protein that shares a region of high homology to the tumor suppressor protein Mig6, a modulator of EGFR. The vertebrate Acks make up the only tyrosine kinase (TK) family known to carry a UBA domain. The GTPase binding and SAM domains are also uncommon in the NRTKs. In addition to being a downstream effector of receptor tyrosine kinases (RTKs) and integrins, Ack1 can act as an epigenetic regulator, modulate the degradation of the epidermal growth factor receptor (EGFR), confer drug resistance, and mediate the progression of hormone-sensitive tumors. In this review, we discuss the domain architecture of Ack1 in relation to other protein kinases that possess such defined regulatory domains.https://www.mdpi.com/2073-4409/12/6/900nonreceptor tyrosine kinaseAck1SAM domainactivated Cdc42-associated kinaseubiquitin-associated domain |
| spellingShingle | Yagmur Kan YiTing Paung Markus A. Seeliger W. Todd Miller Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1 Cells nonreceptor tyrosine kinase Ack1 SAM domain activated Cdc42-associated kinase ubiquitin-associated domain |
| title | Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1 |
| title_full | Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1 |
| title_fullStr | Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1 |
| title_full_unstemmed | Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1 |
| title_short | Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1 |
| title_sort | domain architecture of the nonreceptor tyrosine kinase ack1 |
| topic | nonreceptor tyrosine kinase Ack1 SAM domain activated Cdc42-associated kinase ubiquitin-associated domain |
| url | https://www.mdpi.com/2073-4409/12/6/900 |
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