Pulmonary Mucinous Adenocarcinoma Combined with Bronchial Squamous Cell Papilloma and Infection with Tropheryma Whipplei: A Case Report
Simultaneous multiple primary tumors on the same side of the lung with Tropheryma whipplei (TW) infection are rare. We reviewed the clinical data, imaging manifestations, pathological results, diagnosis and treatment of a primary pulmonary mucinous adenocarcinoma (PPMA) patient with bronchial squamo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2023-07-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2023.106.13 |
| _version_ | 1797687464388722688 |
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| author | Xiaolei YUE Xiaoxia XI Min ZHANG Junyu BIAN Yonglin CHEN |
| author_facet | Xiaolei YUE Xiaoxia XI Min ZHANG Junyu BIAN Yonglin CHEN |
| author_sort | Xiaolei YUE |
| collection | DOAJ |
| description | Simultaneous multiple primary tumors on the same side of the lung with Tropheryma whipplei (TW) infection are rare. We reviewed the clinical data, imaging manifestations, pathological results, diagnosis and treatment of a primary pulmonary mucinous adenocarcinoma (PPMA) patient with bronchial squamous cell papilloma (BSCP) and TW infection, and discussed our treatment experience. The patient mainly presented with chronic cough and sputum, and computed tomography (CT) showed inflammatory changes with multiple nodular shadows. Biopsy of the lower lobe of the right lung showed PPMA, and right lung sub-branchial nodules discovered during bronchoscope revealed BSCP. Metagenomics next generation sequencing (mNGS) of bronchoalveolar lavage fluid showed mixed infection of Streptococcus pneumoniae and TW with a poor anti-infective effect. No clear genetic mutation was detected, and the patient was treated with chemotherapy and regularly followed up. We should improve the awareness of multiple pulmonary pathologies during clinical practice, avoid missed diagnosis and misdiagnosis, and carry out comprehensive treatment after clarifying the diagnosis as soon as possible. |
| first_indexed | 2024-03-12T01:19:24Z |
| format | Article |
| id | doaj.art-40090bda0f034e469b2a13a7aee7bdcb |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-03-12T01:19:24Z |
| publishDate | 2023-07-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-40090bda0f034e469b2a13a7aee7bdcb2023-09-13T08:32:42ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872023-07-0126755355810.3779/j.issn.1009-3419.2023.106.13Pulmonary Mucinous Adenocarcinoma Combined with Bronchial Squamous Cell
Papilloma and Infection with Tropheryma Whipplei: A Case ReportXiaolei YUE0Xiaoxia XI1Min ZHANG2Junyu BIAN3Yonglin CHEN4The First Clinical Medical School of Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical School of Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical School of Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical School of Lanzhou University, Lanzhou 730000, ChinaDepartment of Pathology, The First Hospital of Lanzhou University, Lanzhou 730000, ChinaSimultaneous multiple primary tumors on the same side of the lung with Tropheryma whipplei (TW) infection are rare. We reviewed the clinical data, imaging manifestations, pathological results, diagnosis and treatment of a primary pulmonary mucinous adenocarcinoma (PPMA) patient with bronchial squamous cell papilloma (BSCP) and TW infection, and discussed our treatment experience. The patient mainly presented with chronic cough and sputum, and computed tomography (CT) showed inflammatory changes with multiple nodular shadows. Biopsy of the lower lobe of the right lung showed PPMA, and right lung sub-branchial nodules discovered during bronchoscope revealed BSCP. Metagenomics next generation sequencing (mNGS) of bronchoalveolar lavage fluid showed mixed infection of Streptococcus pneumoniae and TW with a poor anti-infective effect. No clear genetic mutation was detected, and the patient was treated with chemotherapy and regularly followed up. We should improve the awareness of multiple pulmonary pathologies during clinical practice, avoid missed diagnosis and misdiagnosis, and carry out comprehensive treatment after clarifying the diagnosis as soon as possible.http://dx.doi.org/10.3779/j.issn.1009-3419.2023.106.13lung neoplasmspulmonary mucinous adenocarcinomasquamous cell papillomatropheryma whipplei |
| spellingShingle | Xiaolei YUE Xiaoxia XI Min ZHANG Junyu BIAN Yonglin CHEN Pulmonary Mucinous Adenocarcinoma Combined with Bronchial Squamous Cell Papilloma and Infection with Tropheryma Whipplei: A Case Report Chinese Journal of Lung Cancer lung neoplasms pulmonary mucinous adenocarcinoma squamous cell papilloma tropheryma whipplei |
| title | Pulmonary Mucinous Adenocarcinoma Combined with Bronchial Squamous Cell
Papilloma and Infection with Tropheryma Whipplei: A Case Report |
| title_full | Pulmonary Mucinous Adenocarcinoma Combined with Bronchial Squamous Cell
Papilloma and Infection with Tropheryma Whipplei: A Case Report |
| title_fullStr | Pulmonary Mucinous Adenocarcinoma Combined with Bronchial Squamous Cell
Papilloma and Infection with Tropheryma Whipplei: A Case Report |
| title_full_unstemmed | Pulmonary Mucinous Adenocarcinoma Combined with Bronchial Squamous Cell
Papilloma and Infection with Tropheryma Whipplei: A Case Report |
| title_short | Pulmonary Mucinous Adenocarcinoma Combined with Bronchial Squamous Cell
Papilloma and Infection with Tropheryma Whipplei: A Case Report |
| title_sort | pulmonary mucinous adenocarcinoma combined with bronchial squamous cell
papilloma and infection with tropheryma whipplei a case report |
| topic | lung neoplasms pulmonary mucinous adenocarcinoma squamous cell papilloma tropheryma whipplei |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2023.106.13 |
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