Epithelial miR-206 targets CD39/extracellular ATP to upregulate airway IL-25 and TSLP in type 2–high asthma

Epithelial miR-206 targets CD39/extracellular ATP to upregulate airway IL-25 and TSLP in type 2–high asthma

The epithelial cell–derived cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) initiate type 2 inflammation in allergic diseases, including asthma. However, the signaling pathway regulating these cytokines expression remains elusive. Since microRNAs are pivotal regulators of gene expres...

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Bibliographic Details
Main Authors: Kan Zhang, Yuchen Feng, Yuxia Liang, Wenliang Wu, Chenli Chang, Dian Chen, Shengchong Chen, Jiali Gao, Gongqi Chen, Lingling Yi, Dan Cheng, Guohua Zhen
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-06-01
Series:JCI Insight
Subjects:
Pulmonology
Online Access:https://doi.org/10.1172/jci.insight.148103

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