Subunit Vaccines Using TLR Triagonist Combination Adjuvants Provide Protection Against Coxiella burnetii While Minimizing Reactogenic Responses

Subunit Vaccines Using TLR Triagonist Combination Adjuvants Provide Protection Against Coxiella burnetii While Minimizing Reactogenic Responses

Q fever is caused by the obligate intracellular bacterium, Coxiella burnetii, a designated potential agent of bioterrorism because of its route of transmission, resistance to disinfectants, and low infectious dose. The only vaccine licensed for human use is Q-VAX® (Seqirus, licensed in Australia), a...

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Bibliographic Details
Main Authors: Alycia P. Fratzke, Sharon Jan, Jiin Felgner, Li Liang, Rie Nakajima, Algis Jasinskas, Saikat Manna, Fnu N. Nihesh, Sampa Maiti, Tyler J. Albin, Aaron P. Esser-Kahn, D. Huw Davies, James E. Samuel, Philip L. Felgner, Anthony E. Gregory
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
Coxiella burnetii
guinea pig model
hypersensitivity
vaccine
TLR agonist
triagonist
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.653092/full

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