Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques
Atherosclerosis, a systematic degenerative disease related to the buildup of plaques in human vessels, remains the major cause of morbidity in the field of cardiovascular health problems, which are the number one cause of death globally. Novel atheroprotective HDL-mimicking chemically modified carbo...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/7/802 |
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| author | Shamil Akhmedov Sergey Afanasyev Marina Trusova Pavel Postnikov Yulia Rogovskaya Elena Grakova Kristina Kopeva Rosa Karen Carreon Paz Sascha Balakin Hans-Peter Wiesmann Joerg Opitz Benjamin Kruppke Natalia Beshchasna Sergey Popov |
| author_facet | Shamil Akhmedov Sergey Afanasyev Marina Trusova Pavel Postnikov Yulia Rogovskaya Elena Grakova Kristina Kopeva Rosa Karen Carreon Paz Sascha Balakin Hans-Peter Wiesmann Joerg Opitz Benjamin Kruppke Natalia Beshchasna Sergey Popov |
| author_sort | Shamil Akhmedov |
| collection | DOAJ |
| description | Atherosclerosis, a systematic degenerative disease related to the buildup of plaques in human vessels, remains the major cause of morbidity in the field of cardiovascular health problems, which are the number one cause of death globally. Novel atheroprotective HDL-mimicking chemically modified carbon-coated iron nanoparticles (Fe@C NPs) were produced by gas-phase synthesis and modified with organic functional groups of a lipophilic nature. Modified and non-modified Fe@C NPs, immobilized with polycaprolactone on stainless steel, showed high cytocompatibility in human endothelial cell culture. Furthermore, after ex vivo treatment of native atherosclerotic plaques obtained during open carotid endarterectomy surgery, Fe@C NPs penetrated the inner structures and caused structural changes of atherosclerotic plaques, depending on the period of implantation in Wistar rats, serving as a natural bioreactor. The high biocompatibility of the Fe@C NPs shows great potential in the treatment of atherosclerosis disease as an active substance of stent coatings to prevent restenosis and the formation of atherosclerotic plaques. |
| first_indexed | 2024-03-10T09:44:51Z |
| format | Article |
| id | doaj.art-400cf5484b5148a491f0eab7f66d20ab |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T09:44:51Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-400cf5484b5148a491f0eab7f66d20ab2023-11-22T03:17:16ZengMDPI AGBiomedicines2227-90592021-07-019780210.3390/biomedicines9070802Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic PlaquesShamil Akhmedov0Sergey Afanasyev1Marina Trusova2Pavel Postnikov3Yulia Rogovskaya4Elena Grakova5Kristina Kopeva6Rosa Karen Carreon Paz7Sascha Balakin8Hans-Peter Wiesmann9Joerg Opitz10Benjamin Kruppke11Natalia Beshchasna12Sergey Popov13Tomsk National Research Medical Center of the Russian Academy of Sciences, Cardiology Research Institute, 634012 Tomsk, RussiaTomsk National Research Medical Center of the Russian Academy of Sciences, Cardiology Research Institute, 634012 Tomsk, RussiaResearch School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, RussiaResearch School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, RussiaTomsk National Research Medical Center of the Russian Academy of Sciences, Cardiology Research Institute, 634012 Tomsk, RussiaTomsk National Research Medical Center of the Russian Academy of Sciences, Cardiology Research Institute, 634012 Tomsk, RussiaTomsk National Research Medical Center of the Russian Academy of Sciences, Cardiology Research Institute, 634012 Tomsk, RussiaFraunhofer Institute for Ceramic Technologies and Systems IKTS, 01109 Dresden, GermanyFraunhofer Institute for Ceramic Technologies and Systems IKTS, 01109 Dresden, GermanyMax Bergmann Center of Biomaterials, Institute of Materials Science, Technische Universität Dresden, 01069 Dresden, GermanyFraunhofer Institute for Ceramic Technologies and Systems IKTS, 01109 Dresden, GermanyMax Bergmann Center of Biomaterials, Institute of Materials Science, Technische Universität Dresden, 01069 Dresden, GermanyFraunhofer Institute for Ceramic Technologies and Systems IKTS, 01109 Dresden, GermanyTomsk National Research Medical Center of the Russian Academy of Sciences, Cardiology Research Institute, 634012 Tomsk, RussiaAtherosclerosis, a systematic degenerative disease related to the buildup of plaques in human vessels, remains the major cause of morbidity in the field of cardiovascular health problems, which are the number one cause of death globally. Novel atheroprotective HDL-mimicking chemically modified carbon-coated iron nanoparticles (Fe@C NPs) were produced by gas-phase synthesis and modified with organic functional groups of a lipophilic nature. Modified and non-modified Fe@C NPs, immobilized with polycaprolactone on stainless steel, showed high cytocompatibility in human endothelial cell culture. Furthermore, after ex vivo treatment of native atherosclerotic plaques obtained during open carotid endarterectomy surgery, Fe@C NPs penetrated the inner structures and caused structural changes of atherosclerotic plaques, depending on the period of implantation in Wistar rats, serving as a natural bioreactor. The high biocompatibility of the Fe@C NPs shows great potential in the treatment of atherosclerosis disease as an active substance of stent coatings to prevent restenosis and the formation of atherosclerotic plaques.https://www.mdpi.com/2227-9059/9/7/802atherosclerosishigh density lipoproteinchemically modified carbon-coated iron nanoparticlereverse cholesterol transportmacrophagecoronary stent |
| spellingShingle | Shamil Akhmedov Sergey Afanasyev Marina Trusova Pavel Postnikov Yulia Rogovskaya Elena Grakova Kristina Kopeva Rosa Karen Carreon Paz Sascha Balakin Hans-Peter Wiesmann Joerg Opitz Benjamin Kruppke Natalia Beshchasna Sergey Popov Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques Biomedicines atherosclerosis high density lipoprotein chemically modified carbon-coated iron nanoparticle reverse cholesterol transport macrophage coronary stent |
| title | Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques |
| title_full | Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques |
| title_fullStr | Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques |
| title_full_unstemmed | Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques |
| title_short | Chemically Modified Biomimetic Carbon-Coated Iron Nanoparticles for Stent Coatings: In Vitro Cytocompatibility and In Vivo Structural Changes in Human Atherosclerotic Plaques |
| title_sort | chemically modified biomimetic carbon coated iron nanoparticles for stent coatings in vitro cytocompatibility and in vivo structural changes in human atherosclerotic plaques |
| topic | atherosclerosis high density lipoprotein chemically modified carbon-coated iron nanoparticle reverse cholesterol transport macrophage coronary stent |
| url | https://www.mdpi.com/2227-9059/9/7/802 |
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