Hepatitis E Virus (HEV)-Specific T Cell Receptor Cross-Recognition: Implications for Immunotherapy

Hepatitis E Virus (HEV)-Specific T Cell Receptor Cross-Recognition: Implications for Immunotherapy

T cell immunotherapy is a concept developed for the treatment of cancer and infectious diseases, based on cytotoxic T lymphocytes to target tumor- or pathogen-specific antigens. Antigen-specificity of the T cell receptors (TCRs) is an important selection criterion in the developmental design of immu...

Full description

Bibliographic Details
Main Authors:	Chai Fen Soon, Shihong Zhang, Pothakamuri Venkata Suneetha, Dinler Amaral Antunes, Michael Peter Manns, Solaiman Raha, Christian Schultze-Florey, Immo Prinz, Heiner Wedemeyer, Margaret Sällberg Chen, Markus Cornberg
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-09-01
Series:	Frontiers in Immunology
Subjects:	CD8+ T cells cross-reactivity T cell therapy immunotherapy T cell receptor (TCR) TCR redirection
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2019.02076/full

Similar Items

Editorial: Quantification and prediction of T-cell cross-reactivity through experimental and computational methods
by: Dinler A. Antunes, et al.
Published: (2024-02-01)

Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy
by: Sarina Ravens, et al.
Published: (2018-03-01)

Cytomegalovirus-Driven Adaptive-Like Natural Killer Cell Expansions Are Unaffected by Concurrent Chronic Hepatitis Virus Infections
by: David F. G. Malone, et al.
Published: (2017-05-01)

Interpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer Immunotherapy
by: Dinler A. Antunes, et al.
Published: (2017-10-01)

Human γδ TCR Repertoires in Health and Disease
by: Alina Suzann Fichtner, et al.
Published: (2020-03-01)

Systematic pattern analyses of Vδ2+ TCRs reveal that shared “public” Vδ2+ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status
by: Lihua Deng, et al.
Published: (2022-09-01)

Corrigendum: Systematic pattern analyses of Vδ2+ TCRs reveal that shared “public” Vδ2+ γδ T cell clones are a consequence of rearrangement bias and a higher expansion status
by: Lihua Deng, et al.
Published: (2022-10-01)

Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles
by: Andreas Walker, et al.
Published: (2022-11-01)

Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies
by: Katie Healy, et al.
Published: (2020-06-01)

Effects of renin–angiotensin inhibitors on renal function and the clinical course in patients with decompensated cirrhosis
by: Tammo L. Tergast, et al.
Published: (2023-10-01)

New approaches and therapeutic modalities for the treatment of patients with chronic hepatitis C
by: Markus Cornberg, et al.
Published: (2005-07-01)

Individual Epitope-Specific CD8<sup>+</sup> T Cell Immune Responses Are Shaped Differently during Chronic Viral Infection
by: Sebastian Klein, et al.
Published: (2023-05-01)

Performance comparison of TCR-pMHC prediction tools reveals a strong data dependency
by: Lihua Deng, et al.
Published: (2023-04-01)

Kinetics and Value of Hepatitis B Core-Related Antigen in Patients with Chronic Hepatitis B Virus Infection during Antiviral Treatment
by: Lisa Sandmann, et al.
Published: (2024-02-01)

Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy
by: Berislav Bošnjak, et al.
Published: (2021-08-01)

Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells.
by: Verena Schlaphoff, et al.
Published: (2011-05-01)

Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity
by: Benedikt Strunz, et al.
Published: (2018-06-01)

Cross-Reactive T Cell Response Exists in Chronic Lymphocytic Choriomeningitis Virus Infection upon Pichinde Virus Challenge
by: Jasmin Mischke, et al.
Published: (2022-10-01)

T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation
by: Amalie Kai Bentzen, et al.
Published: (2019-09-01)

Longitudinal Tracking of Immune Responses in COVID-19 Convalescents Reveals Absence of Neutralization Activity Against Omicron and Staggered Impairment to Other SARS-CoV-2 Variants of Concern
by: Ivan Odak, et al.
Published: (2022-03-01)

Reappearance of effector T cells is associated with recovery from COVID-19
by: Ivan Odak, et al.
Published: (2020-07-01)

The Quest for the Best: How TCR Affinity, Avidity, and Functional Avidity Affect TCR-Engineered T-Cell Antitumor Responses
by: Diana Campillo-Davo, et al.
Published: (2020-07-01)

Improving the Safety of Cell Therapy Products by Suicide Gene Transfer
by: Antonio eDi Stasi, et al.
Published: (2014-11-01)

Detection of mutant antigen-specific T cell receptors against multiple myeloma for T cell engineering
by: Masahiro Okada, et al.
Published: (2023-06-01)

Process Development for Adoptive Cell Therapy in Academia: A Pipeline for Clinical-Scale Manufacturing of Multiple TCR-T Cell Products
by: Daniela Nascimento Silva, et al.
Published: (2022-06-01)

Increasing Number of Individuals Receiving Hepatitis B nucleos(t)ide Analogs Therapy in Germany, 2008–2019
by: Anna Maisa, et al.
Published: (2021-05-01)

Dynamic evolution of the sofosbuvir-associated variant A1343V in HEV-infected patients under concomitant sofosbuvir-ribavirin treatment
by: André Gömer, et al.
Published: (2024-03-01)

pyTCR: A comprehensive and scalable solution for TCR-Seq data analysis to facilitate reproducibility and rigor of immunogenomics research
by: Kerui Peng, et al.
Published: (2022-10-01)

Overview of methodologies for T-cell receptor repertoire analysis
by: Elisa Rosati, et al.
Published: (2017-07-01)

Immunogenic self-peptides - the great unknowns in autoimmunity: Identifying T-cell epitopes driving the autoimmune response in autoimmune diseases
by: Jörg Christoph Prinz
Published: (2023-01-01)

Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer
by: Stefan Audehm, et al.
Published: (2019-06-01)

TCR-Engineered Lymphocytes Targeting NY-ESO-1: In Vitro Assessment of Cytotoxicity against Tumors
by: Alaa Alsalloum, et al.
Published: (2023-10-01)

Modifications outside CDR1, 2 and 3 of the TCR variable β domain increase TCR expression and antigen-specific function
by: Abdullah Degirmencay, et al.
Published: (2023-04-01)

Controlled Attenuation Parameter Is Associated with a Distinct Systemic Inflammatory Milieu after Clearance of HCV Infection
by: Yanqin Du, et al.
Published: (2023-05-01)

Clonal exhaustion as a mechanism to protect against severe immunopathology and death from an overwhelming CD8 T cell response.
by: Markus eCornberg, et al.
Published: (2013-12-01)

Eligibility and safety of triple therapy for hepatitis C: lessons learned from the first experience in a real world setting.
by: Benjamin Maasoumy, et al.
Published: (2013-01-01)

A Framework to Identify Antigen-Expanded T Cell Receptor Clusters Within Complex Repertoires
by: Valentina Ceglia, et al.
Published: (2021-11-01)

T-cell virtuosity in ‘‘knowing thyself”
by: Oreste Acuto
Published: (2024-02-01)

Clonality of CD4+ Blood T Cells Predicts Longer Survival With CTLA4 or PD-1 Checkpoint Inhibition in Advanced Melanoma
by: Akiko Arakawa, et al.
Published: (2019-06-01)

CROSS-REACTIVITY OF TCR REPERTOIRE: CURRENT CONCEPTS, CHALLENGES AND IMPLICATION FOR ALLOTRANSPLANTATION
by: Nicolas eDegauque, et al.
Published: (2016-03-01)