Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable angina
Abstract We assessed whether high triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, expressed by an increased TG/HDL-C ratio, predict coronary atherosclerotic disease (CAD) outcomes in patients with stable angina. We studied 355 patients (60 ± 9 years, 211 males) with s...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-00020-3 |
| _version_ | 1819259707724922880 |
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| author | Chiara Caselli Raffaele De Caterina Jeff M Smit Jonica Campolo Mohammed El Mahdiui Rosetta Ragusa Alberto Clemente Tiziana Sampietro Aldo Clerico Riccardo Liga Gualtiero Pelosi Silvia Rocchiccioli Oberdan Parodi Arthur Scholte Jhuani Knuuti Danilo Neglia EVINCI and SMARTool |
| author_facet | Chiara Caselli Raffaele De Caterina Jeff M Smit Jonica Campolo Mohammed El Mahdiui Rosetta Ragusa Alberto Clemente Tiziana Sampietro Aldo Clerico Riccardo Liga Gualtiero Pelosi Silvia Rocchiccioli Oberdan Parodi Arthur Scholte Jhuani Knuuti Danilo Neglia EVINCI and SMARTool |
| author_sort | Chiara Caselli |
| collection | DOAJ |
| description | Abstract We assessed whether high triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, expressed by an increased TG/HDL-C ratio, predict coronary atherosclerotic disease (CAD) outcomes in patients with stable angina. We studied 355 patients (60 ± 9 years, 211 males) with stable angina who underwent coronary computed tomography angiography (CTA), were managed clinically and followed for 4.5 ± 0.9 years. The primary composite outcome was all-cause mortality and non-fatal myocardial infarction. At baseline, the proportion of males, patients with metabolic syndrome, diabetes and obstructive CAD increased across TG/HDL-C ratio quartiles, together with markers of insulin resistance, hepatic and adipose tissue dysfunction and myocardial damage, with no difference in total cholesterol or LDL-C. At follow-up, the global CTA risk score (HR 1.06, 95% confidence interval (CI) 1.03–1.09, P = 0.001) and the IV quartile of the TG/HDL-C ratio (HR 2.85, 95% CI 1.30–6.26, P < 0.01) were the only independent predictors of the primary outcome. The TG/HDL-C ratio and the CTA risk score progressed over time despite increased use of lipid-lowering drugs and reduction in LDL-C. In patients with stable angina, high TG and low HDL-C levels are associated with CAD related outcomes independently of LDL-C and treatments. Trial registration. EVINCI study: ClinicalTrials.gov NCT00979199, registered September 17, 2009; SMARTool study: ClinicalTrials.gov NCT04448691, registered June 26, 2020. |
| first_indexed | 2024-12-23T19:14:18Z |
| format | Article |
| id | doaj.art-400fcea6ae5041d587ad339d48050228 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-23T19:14:18Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-400fcea6ae5041d587ad339d480502282022-12-21T17:34:21ZengNature PortfolioScientific Reports2045-23222021-10-0111111210.1038/s41598-021-00020-3Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable anginaChiara Caselli0Raffaele De Caterina1Jeff M Smit2Jonica Campolo3Mohammed El Mahdiui4Rosetta Ragusa5Alberto Clemente6Tiziana Sampietro7Aldo Clerico8Riccardo Liga9Gualtiero Pelosi10Silvia Rocchiccioli11Oberdan Parodi12Arthur Scholte13Jhuani Knuuti14Danilo Neglia15EVINCI and SMARToolInstitute of Clinical Physiology CNRCardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria PisanaDepartment of Cardiology, Leiden University Medical CentreInstitute of Clinical Physiology CNR, ASST Grande Ospedale Metropolitano NiguardaDepartment of Cardiology, Leiden University Medical CentreInstitute of Clinical Physiology CNRCardiovascular Department, Fondazione Toscana G. MonasterioCardiovascular Department, Fondazione Toscana G. MonasterioCardiovascular Department, Fondazione Toscana G. MonasterioCardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria PisanaInstitute of Clinical Physiology CNRInstitute of Clinical Physiology CNRInstitute of Clinical Physiology CNRDepartment of Cardiology, Leiden University Medical CentrePET Center, Turku University Hospital and University of TurkuCardiovascular Department, Fondazione Toscana G. MonasterioAbstract We assessed whether high triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) levels, expressed by an increased TG/HDL-C ratio, predict coronary atherosclerotic disease (CAD) outcomes in patients with stable angina. We studied 355 patients (60 ± 9 years, 211 males) with stable angina who underwent coronary computed tomography angiography (CTA), were managed clinically and followed for 4.5 ± 0.9 years. The primary composite outcome was all-cause mortality and non-fatal myocardial infarction. At baseline, the proportion of males, patients with metabolic syndrome, diabetes and obstructive CAD increased across TG/HDL-C ratio quartiles, together with markers of insulin resistance, hepatic and adipose tissue dysfunction and myocardial damage, with no difference in total cholesterol or LDL-C. At follow-up, the global CTA risk score (HR 1.06, 95% confidence interval (CI) 1.03–1.09, P = 0.001) and the IV quartile of the TG/HDL-C ratio (HR 2.85, 95% CI 1.30–6.26, P < 0.01) were the only independent predictors of the primary outcome. The TG/HDL-C ratio and the CTA risk score progressed over time despite increased use of lipid-lowering drugs and reduction in LDL-C. In patients with stable angina, high TG and low HDL-C levels are associated with CAD related outcomes independently of LDL-C and treatments. Trial registration. EVINCI study: ClinicalTrials.gov NCT00979199, registered September 17, 2009; SMARTool study: ClinicalTrials.gov NCT04448691, registered June 26, 2020.https://doi.org/10.1038/s41598-021-00020-3 |
| spellingShingle | Chiara Caselli Raffaele De Caterina Jeff M Smit Jonica Campolo Mohammed El Mahdiui Rosetta Ragusa Alberto Clemente Tiziana Sampietro Aldo Clerico Riccardo Liga Gualtiero Pelosi Silvia Rocchiccioli Oberdan Parodi Arthur Scholte Jhuani Knuuti Danilo Neglia EVINCI and SMARTool Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable angina Scientific Reports |
| title | Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable angina |
| title_full | Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable angina |
| title_fullStr | Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable angina |
| title_full_unstemmed | Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable angina |
| title_short | Triglycerides and low HDL cholesterol predict coronary heart disease risk in patients with stable angina |
| title_sort | triglycerides and low hdl cholesterol predict coronary heart disease risk in patients with stable angina |
| url | https://doi.org/10.1038/s41598-021-00020-3 |
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