Conditioned increase of locomotor activity induced by haloperidol.
Dopamine antagonist drugs have profound effects on locomotor activity. In particular, the administration of the D2 antagonist haloperidol produces a state that is similar to catalepsy. In order to confirm whether the modulation of the dopaminergic activity produced by haloperidol can act as an uncon...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6169844?pdf=render |
| _version_ | 1818623593831989248 |
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| author | Luis Gonzalo De la Casa Lucía Cárcel Juan Carlos Ruiz-Salas Lucía Vicente Auxiliadora Mena |
| author_facet | Luis Gonzalo De la Casa Lucía Cárcel Juan Carlos Ruiz-Salas Lucía Vicente Auxiliadora Mena |
| author_sort | Luis Gonzalo De la Casa |
| collection | DOAJ |
| description | Dopamine antagonist drugs have profound effects on locomotor activity. In particular, the administration of the D2 antagonist haloperidol produces a state that is similar to catalepsy. In order to confirm whether the modulation of the dopaminergic activity produced by haloperidol can act as an unconditioned stimulus, we carried out two experiments in which the administration of haloperidol was repeatedly paired with the presence of distinctive contextual cues that served as a Conditioned Stimulus. Paradoxically, the results revealed a dose-dependent increase in locomotor activity following conditioning with dopamine antagonist (Experiments 1) that was susceptible of extinction when the conditioned stimulus was presented repeatedly by itself after conditioning (Experiment 2). These data are interpreted from an associative perspective, considering them as a result of a classical conditioning process. |
| first_indexed | 2024-12-16T18:43:32Z |
| format | Article |
| id | doaj.art-4012ff90efb345bc88eb9cebb63fe6eb |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T18:43:32Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4012ff90efb345bc88eb9cebb63fe6eb2022-12-21T22:20:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e020017810.1371/journal.pone.0200178Conditioned increase of locomotor activity induced by haloperidol.Luis Gonzalo De la CasaLucía CárcelJuan Carlos Ruiz-SalasLucía VicenteAuxiliadora MenaDopamine antagonist drugs have profound effects on locomotor activity. In particular, the administration of the D2 antagonist haloperidol produces a state that is similar to catalepsy. In order to confirm whether the modulation of the dopaminergic activity produced by haloperidol can act as an unconditioned stimulus, we carried out two experiments in which the administration of haloperidol was repeatedly paired with the presence of distinctive contextual cues that served as a Conditioned Stimulus. Paradoxically, the results revealed a dose-dependent increase in locomotor activity following conditioning with dopamine antagonist (Experiments 1) that was susceptible of extinction when the conditioned stimulus was presented repeatedly by itself after conditioning (Experiment 2). These data are interpreted from an associative perspective, considering them as a result of a classical conditioning process.http://europepmc.org/articles/PMC6169844?pdf=render |
| spellingShingle | Luis Gonzalo De la Casa Lucía Cárcel Juan Carlos Ruiz-Salas Lucía Vicente Auxiliadora Mena Conditioned increase of locomotor activity induced by haloperidol. PLoS ONE |
| title | Conditioned increase of locomotor activity induced by haloperidol. |
| title_full | Conditioned increase of locomotor activity induced by haloperidol. |
| title_fullStr | Conditioned increase of locomotor activity induced by haloperidol. |
| title_full_unstemmed | Conditioned increase of locomotor activity induced by haloperidol. |
| title_short | Conditioned increase of locomotor activity induced by haloperidol. |
| title_sort | conditioned increase of locomotor activity induced by haloperidol |
| url | http://europepmc.org/articles/PMC6169844?pdf=render |
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