Neuropathic pain in children: Steps towards improved recognition and management
Neuropathic pain in children can be severe and persistent, difficult to recognise and manage, and associated with significant pain-related disability. Recognition based on clinical history and sensory descriptors is challenging in young children, and screening tools require further validation at old...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396420305004 |
| _version_ | 1818928288561627136 |
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| author | Suellen M Walker |
| author_facet | Suellen M Walker |
| author_sort | Suellen M Walker |
| collection | DOAJ |
| description | Neuropathic pain in children can be severe and persistent, difficult to recognise and manage, and associated with significant pain-related disability. Recognition based on clinical history and sensory descriptors is challenging in young children, and screening tools require further validation at older ages. Confirmatory tests can identify the disease or lesion of the somatosensory nervous system resulting in neuropathic pain, but feasibility and interpretation may be influenced by age- and sex-dependent changes throughout development. Quantitative sensory testing identifies specific mechanism-related sensory profiles; brain imaging is a potential biomarker of alterations in central processing and modulation of both sensory and affective components of pain; and genetic analysis can reveal known and new causes of neuropathic pain. Alongside existing patient- and parent-reported outcome measures, somatosensory system research methodologies and validation of mechanism-based standardised end-points may inform individualised therapy and stratification for clinical trials that will improve evidence-based management of neuropathic pain in children. |
| first_indexed | 2024-12-20T03:26:32Z |
| format | Article |
| id | doaj.art-40130da510db498483cac923c24984df |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-20T03:26:32Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-40130da510db498483cac923c24984df2022-12-21T19:55:05ZengElsevierEBioMedicine2352-39642020-12-0162103124Neuropathic pain in children: Steps towards improved recognition and managementSuellen M Walker0Developmental Neurosciences Program, UCL Great Ormond St Institute of Child Health, London, United Kingdom; Department of Anaesthesia and Pain Medicine, Great Ormond St Hospital NHS Foundation Trust, London, United Kingdom; Correspondence address: UCL Great Ormond Street Institute of Child Health, Clinical Neurosciences (Pain Research), 4th Floor PUW South, 30 Guilford St., London WC1N 1EH, United Kingdom.Neuropathic pain in children can be severe and persistent, difficult to recognise and manage, and associated with significant pain-related disability. Recognition based on clinical history and sensory descriptors is challenging in young children, and screening tools require further validation at older ages. Confirmatory tests can identify the disease or lesion of the somatosensory nervous system resulting in neuropathic pain, but feasibility and interpretation may be influenced by age- and sex-dependent changes throughout development. Quantitative sensory testing identifies specific mechanism-related sensory profiles; brain imaging is a potential biomarker of alterations in central processing and modulation of both sensory and affective components of pain; and genetic analysis can reveal known and new causes of neuropathic pain. Alongside existing patient- and parent-reported outcome measures, somatosensory system research methodologies and validation of mechanism-based standardised end-points may inform individualised therapy and stratification for clinical trials that will improve evidence-based management of neuropathic pain in children.http://www.sciencedirect.com/science/article/pii/S2352396420305004Neuropathic painChildrenAdolescentsQuantitative sensory testingNeuropathyChronic pain |
| spellingShingle | Suellen M Walker Neuropathic pain in children: Steps towards improved recognition and management EBioMedicine Neuropathic pain Children Adolescents Quantitative sensory testing Neuropathy Chronic pain |
| title | Neuropathic pain in children: Steps towards improved recognition and management |
| title_full | Neuropathic pain in children: Steps towards improved recognition and management |
| title_fullStr | Neuropathic pain in children: Steps towards improved recognition and management |
| title_full_unstemmed | Neuropathic pain in children: Steps towards improved recognition and management |
| title_short | Neuropathic pain in children: Steps towards improved recognition and management |
| title_sort | neuropathic pain in children steps towards improved recognition and management |
| topic | Neuropathic pain Children Adolescents Quantitative sensory testing Neuropathy Chronic pain |
| url | http://www.sciencedirect.com/science/article/pii/S2352396420305004 |
| work_keys_str_mv | AT suellenmwalker neuropathicpaininchildrenstepstowardsimprovedrecognitionandmanagement |