Cyclic Stretch Negatively Regulates IL-1β Secretion Through the Inhibition of NLRP3 Inflammasome Activation by Attenuating the AMP Kinase Pathway

Cyclic Stretch Negatively Regulates IL-1β Secretion Through the Inhibition of NLRP3 Inflammasome Activation by Attenuating the AMP Kinase Pathway

Macrophages are immune cells of hematopoietic origin that play diverse roles in host defenses and tissue homeostasis. In mechanical microenvironments, macrophages receive mechanical signals that regulate various cellular functions. However, the mechanisms by which mechanical signals influence the ph...

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Bibliographic Details
Main Authors: Kentaro Maruyama, Yukihiko Sakisaka, Mizuki Suto, Hiroyuki Tada, Takashi Nakamura, Satoru Yamada, Eiji Nemoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Physiology
Subjects:
cyclic stretch
inflammasome
macrophage
IL-1β
AMPK
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00802/full

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