Impaired recognition of disgust in amyotrophic lateral sclerosis is related to basal ganglia involvement
In the present study we investigated emotion recognition in pure motor amyotrophic lateral sclerosis (ALS) patients and its relationship with the integrity of basal ganglia, hippocampus and amygdala. Twenty ALS patients without either cognitive or behavioural impairment, and 52 matched healthy contr...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158221002473 |
| _version_ | 1828957510325764096 |
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| author | Veronica Castelnovo Elisa Canu Maria Antonietta Magno Silvia Basaia Nilo Riva Barbara Poletti Vincenzo Silani Massimo Filippi Federica Agosta |
| author_facet | Veronica Castelnovo Elisa Canu Maria Antonietta Magno Silvia Basaia Nilo Riva Barbara Poletti Vincenzo Silani Massimo Filippi Federica Agosta |
| author_sort | Veronica Castelnovo |
| collection | DOAJ |
| description | In the present study we investigated emotion recognition in pure motor amyotrophic lateral sclerosis (ALS) patients and its relationship with the integrity of basal ganglia, hippocampus and amygdala. Twenty ALS patients without either cognitive or behavioural impairment, and 52 matched healthy controls performed a neuropsychological assessment including the Comprehensive Affect Testing System (CATS) investigating emotion recognition. All participants underwent also a 3T brain MRI. Volumes of basal ganglia, hippocampus and amygdala bilaterally were measured using FIRST in FSL. Sociodemographic, cognitive and MRI data were compared between groups. In ALS patients, correlations between CATS significant findings, brain volumes, cognition, mood and behaviour were explored. ALS patients showed altered performances at the CATS total score and, among the investigated emotions, patients were significantly less able to recognize disgust compared with controls. No brain volumetric differences were observed between groups. In ALS patients, a lower performance in disgust recognition was related with a reduced volume of the left pallidum and a lower performance on the Edinburgh Cognitive and Behavioural ALS Screen. Cognitively/behaviourally unimpaired ALS patients showed impaired disgust recognition, which was associated with pallidum volume. The association with cognitive alterations may suggest impaired disgust recognition as an early marker of cognitive decline. |
| first_indexed | 2024-12-14T08:31:18Z |
| format | Article |
| id | doaj.art-401588fe95794ac287eabdc8af2c549e |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-14T08:31:18Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-401588fe95794ac287eabdc8af2c549e2022-12-21T23:09:31ZengElsevierNeuroImage: Clinical2213-15822021-01-0132102803Impaired recognition of disgust in amyotrophic lateral sclerosis is related to basal ganglia involvementVeronica Castelnovo0Elisa Canu1Maria Antonietta Magno2Silvia Basaia3Nilo Riva4Barbara Poletti5Vincenzo Silani6Massimo Filippi7Federica Agosta8Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, ItalyNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, ItalyNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, ItalyNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, ItalyNeurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy; Department of Pathophysiology and Transplantation, “Dino Ferrari” Center, Università degli Studi di Milano, Milan, ItalyNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, ItalyNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy; Corresponding author at: Neuroimaging Research Unit, Division of Neuroscience, and Neurology Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina, 60, 20132 Milan, Italy.In the present study we investigated emotion recognition in pure motor amyotrophic lateral sclerosis (ALS) patients and its relationship with the integrity of basal ganglia, hippocampus and amygdala. Twenty ALS patients without either cognitive or behavioural impairment, and 52 matched healthy controls performed a neuropsychological assessment including the Comprehensive Affect Testing System (CATS) investigating emotion recognition. All participants underwent also a 3T brain MRI. Volumes of basal ganglia, hippocampus and amygdala bilaterally were measured using FIRST in FSL. Sociodemographic, cognitive and MRI data were compared between groups. In ALS patients, correlations between CATS significant findings, brain volumes, cognition, mood and behaviour were explored. ALS patients showed altered performances at the CATS total score and, among the investigated emotions, patients were significantly less able to recognize disgust compared with controls. No brain volumetric differences were observed between groups. In ALS patients, a lower performance in disgust recognition was related with a reduced volume of the left pallidum and a lower performance on the Edinburgh Cognitive and Behavioural ALS Screen. Cognitively/behaviourally unimpaired ALS patients showed impaired disgust recognition, which was associated with pallidum volume. The association with cognitive alterations may suggest impaired disgust recognition as an early marker of cognitive decline.http://www.sciencedirect.com/science/article/pii/S2213158221002473Amyotrophic lateral sclerosisBasal gangliaDisgustEmotionsMRI |
| spellingShingle | Veronica Castelnovo Elisa Canu Maria Antonietta Magno Silvia Basaia Nilo Riva Barbara Poletti Vincenzo Silani Massimo Filippi Federica Agosta Impaired recognition of disgust in amyotrophic lateral sclerosis is related to basal ganglia involvement NeuroImage: Clinical Amyotrophic lateral sclerosis Basal ganglia Disgust Emotions MRI |
| title | Impaired recognition of disgust in amyotrophic lateral sclerosis is related to basal ganglia involvement |
| title_full | Impaired recognition of disgust in amyotrophic lateral sclerosis is related to basal ganglia involvement |
| title_fullStr | Impaired recognition of disgust in amyotrophic lateral sclerosis is related to basal ganglia involvement |
| title_full_unstemmed | Impaired recognition of disgust in amyotrophic lateral sclerosis is related to basal ganglia involvement |
| title_short | Impaired recognition of disgust in amyotrophic lateral sclerosis is related to basal ganglia involvement |
| title_sort | impaired recognition of disgust in amyotrophic lateral sclerosis is related to basal ganglia involvement |
| topic | Amyotrophic lateral sclerosis Basal ganglia Disgust Emotions MRI |
| url | http://www.sciencedirect.com/science/article/pii/S2213158221002473 |
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