Successful treatment with blinatumomab for acute lymphoblastic leukemia in an older adult patient complicated with hepatocarcinoma
An 82-year-old man with Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL) complicated by hepatocarcinoma was presented. Remission induction therapy of hyper-CVAD with half dose reduction achieved hematological complete remission (CR), but accompanied with elevated alanine aminotran...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048924000037 |
| _version_ | 1797322415686025216 |
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| author | Masuho Saburi Masanori Sakata Rika Maruyama Yousuke Kodama Keiichi Uraisami Hiroyuki Takata Yasuhiko Miyazaki Katsuya Kawano Yasuhiro Kodama Eiichi Ohtsuka |
| author_facet | Masuho Saburi Masanori Sakata Rika Maruyama Yousuke Kodama Keiichi Uraisami Hiroyuki Takata Yasuhiko Miyazaki Katsuya Kawano Yasuhiro Kodama Eiichi Ohtsuka |
| author_sort | Masuho Saburi |
| collection | DOAJ |
| description | An 82-year-old man with Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL) complicated by hepatocarcinoma was presented. Remission induction therapy of hyper-CVAD with half dose reduction achieved hematological complete remission (CR), but accompanied with elevated alanine aminotransferase and hyperbilirubinemia. The patient was thought intolerable for hyper-CVAD with half dose reduction due to liver toxicity, and treatment was switched to blinatumomab. Hematological CR was sustained after nine cycles of blinatumomab without exacerbation of liver dysfunction. After five courses of blinatumomab, hepatocarcinoma was treated successfully by trans-arterial chemoembolization. Two years after the diagnosis of ALL, the patient was alive in CR status of ALL. |
| first_indexed | 2024-03-08T05:14:00Z |
| format | Article |
| id | doaj.art-40168ad74a7340298fe7d6a93522697d |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-03-08T05:14:00Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-40168ad74a7340298fe7d6a93522697d2024-02-07T04:44:38ZengElsevierLeukemia Research Reports2213-04892024-01-0121100413Successful treatment with blinatumomab for acute lymphoblastic leukemia in an older adult patient complicated with hepatocarcinomaMasuho Saburi0Masanori Sakata1Rika Maruyama2Yousuke Kodama3Keiichi Uraisami4Hiroyuki Takata5Yasuhiko Miyazaki6Katsuya Kawano7Yasuhiro Kodama8Eiichi Ohtsuka9Department of Hematology, Oita Prefectural Hospital, Bunyo 2-Chome, Oita 870-8511, Japan; Corresponding author.Department of Hematology, Oita Prefectural Hospital, Bunyo 2-Chome, Oita 870-8511, JapanDepartment of Hematology, Oita Prefectural Hospital, Bunyo 2-Chome, Oita 870-8511, JapanDepartment of Hematology, Oita Prefectural Hospital, Bunyo 2-Chome, Oita 870-8511, JapanDepartment of Hematology, Oita Prefectural Hospital, Bunyo 2-Chome, Oita 870-8511, JapanDepartment of Hematology, Oita Prefectural Hospital, Bunyo 2-Chome, Oita 870-8511, JapanDepartment of Hematology, Oita Prefectural Hospital, Bunyo 2-Chome, Oita 870-8511, JapanDepartment of Clinical Laboratory Technology, Oita Prefectural Hospital, Oita, JapanDepartment of Gastroenterology, Oita Prefectural Hospital, Oita, JapanDepartment of Hematology, Oita Prefectural Hospital, Bunyo 2-Chome, Oita 870-8511, JapanAn 82-year-old man with Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL) complicated by hepatocarcinoma was presented. Remission induction therapy of hyper-CVAD with half dose reduction achieved hematological complete remission (CR), but accompanied with elevated alanine aminotransferase and hyperbilirubinemia. The patient was thought intolerable for hyper-CVAD with half dose reduction due to liver toxicity, and treatment was switched to blinatumomab. Hematological CR was sustained after nine cycles of blinatumomab without exacerbation of liver dysfunction. After five courses of blinatumomab, hepatocarcinoma was treated successfully by trans-arterial chemoembolization. Two years after the diagnosis of ALL, the patient was alive in CR status of ALL.http://www.sciencedirect.com/science/article/pii/S2213048924000037Acute lymphoblastic leukemiaBlinatumomabOlder adultHepatic cirrhosisHepatocarcinoma |
| spellingShingle | Masuho Saburi Masanori Sakata Rika Maruyama Yousuke Kodama Keiichi Uraisami Hiroyuki Takata Yasuhiko Miyazaki Katsuya Kawano Yasuhiro Kodama Eiichi Ohtsuka Successful treatment with blinatumomab for acute lymphoblastic leukemia in an older adult patient complicated with hepatocarcinoma Leukemia Research Reports Acute lymphoblastic leukemia Blinatumomab Older adult Hepatic cirrhosis Hepatocarcinoma |
| title | Successful treatment with blinatumomab for acute lymphoblastic leukemia in an older adult patient complicated with hepatocarcinoma |
| title_full | Successful treatment with blinatumomab for acute lymphoblastic leukemia in an older adult patient complicated with hepatocarcinoma |
| title_fullStr | Successful treatment with blinatumomab for acute lymphoblastic leukemia in an older adult patient complicated with hepatocarcinoma |
| title_full_unstemmed | Successful treatment with blinatumomab for acute lymphoblastic leukemia in an older adult patient complicated with hepatocarcinoma |
| title_short | Successful treatment with blinatumomab for acute lymphoblastic leukemia in an older adult patient complicated with hepatocarcinoma |
| title_sort | successful treatment with blinatumomab for acute lymphoblastic leukemia in an older adult patient complicated with hepatocarcinoma |
| topic | Acute lymphoblastic leukemia Blinatumomab Older adult Hepatic cirrhosis Hepatocarcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2213048924000037 |
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