Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation
Insects have evolved several intricate defense mechanisms to adapt to their chemical environment. Due to their versatile capabilities in hydrolytic biotransformation, insect carboxyl/cholinesterases (CCEs) play vital roles in the development of pesticide resistance, facilitating the adaptation of in...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Insects |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4450/14/2/194 |
| _version_ | 1797620252963504128 |
|---|---|
| author | Casey Cruse Timothy Walter Moural Fang Zhu |
| author_facet | Casey Cruse Timothy Walter Moural Fang Zhu |
| author_sort | Casey Cruse |
| collection | DOAJ |
| description | Insects have evolved several intricate defense mechanisms to adapt to their chemical environment. Due to their versatile capabilities in hydrolytic biotransformation, insect carboxyl/cholinesterases (CCEs) play vital roles in the development of pesticide resistance, facilitating the adaptation of insects to their host plants, and manipulating insect behaviors through the olfaction system. CCEs confer insecticide resistance through the mechanisms of qualitative or quantitative changes of CCE-mediated enhanced metabolism or target-site insensitivity, and may contribute to the host plant adaptation. CCEs represent the first odorant-degrading enzymes (ODEs) discovered to degrade insect pheromones and plant odors and remain the most promising ODE candidates. Here, we summarize insect CCE classification, currently characterized insect CCE protein structure characteristics, and the dynamic roles of insect CCEs in chemical adaptation. |
| first_indexed | 2024-03-11T08:38:32Z |
| format | Article |
| id | doaj.art-4019c7f8550b45bea011b2899e66e302 |
| institution | Directory Open Access Journal |
| issn | 2075-4450 |
| language | English |
| last_indexed | 2024-03-11T08:38:32Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Insects |
| spelling | doaj.art-4019c7f8550b45bea011b2899e66e3022023-11-16T21:15:09ZengMDPI AGInsects2075-44502023-02-0114219410.3390/insects14020194Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical AdaptationCasey Cruse0Timothy Walter Moural1Fang Zhu2Department of Entomology, Pennsylvania State University, University Park, State College, PA 16802, USADepartment of Entomology, Pennsylvania State University, University Park, State College, PA 16802, USADepartment of Entomology, Pennsylvania State University, University Park, State College, PA 16802, USAInsects have evolved several intricate defense mechanisms to adapt to their chemical environment. Due to their versatile capabilities in hydrolytic biotransformation, insect carboxyl/cholinesterases (CCEs) play vital roles in the development of pesticide resistance, facilitating the adaptation of insects to their host plants, and manipulating insect behaviors through the olfaction system. CCEs confer insecticide resistance through the mechanisms of qualitative or quantitative changes of CCE-mediated enhanced metabolism or target-site insensitivity, and may contribute to the host plant adaptation. CCEs represent the first odorant-degrading enzymes (ODEs) discovered to degrade insect pheromones and plant odors and remain the most promising ODE candidates. Here, we summarize insect CCE classification, currently characterized insect CCE protein structure characteristics, and the dynamic roles of insect CCEs in chemical adaptation.https://www.mdpi.com/2075-4450/14/2/194metabolic detoxificationhydrolysissequestrationcatalytic triadpesticide resistanceolfaction |
| spellingShingle | Casey Cruse Timothy Walter Moural Fang Zhu Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation Insects metabolic detoxification hydrolysis sequestration catalytic triad pesticide resistance olfaction |
| title | Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation |
| title_full | Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation |
| title_fullStr | Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation |
| title_full_unstemmed | Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation |
| title_short | Dynamic Roles of Insect Carboxyl/Cholinesterases in Chemical Adaptation |
| title_sort | dynamic roles of insect carboxyl cholinesterases in chemical adaptation |
| topic | metabolic detoxification hydrolysis sequestration catalytic triad pesticide resistance olfaction |
| url | https://www.mdpi.com/2075-4450/14/2/194 |
| work_keys_str_mv | AT caseycruse dynamicrolesofinsectcarboxylcholinesterasesinchemicaladaptation AT timothywaltermoural dynamicrolesofinsectcarboxylcholinesterasesinchemicaladaptation AT fangzhu dynamicrolesofinsectcarboxylcholinesterasesinchemicaladaptation |