Concurrent nonavalent human papillomavirus (HPV) vaccination and immune stimulation with imiquimod to treat recalcitrant HPV-associated high grade vaginal intra-epithelial neoplasia
This is the first report describing detailed T cell responses to viral-like proteins contained in an HPV specific vaccine given in combination with Imiquimod for treatment of persistent VAIN2/3. We postulate that stimulation of the innate immune system with Imiquimod and the specific CD4 and CD8T ce...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578924000298 |
| _version_ | 1797234326155296768 |
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| author | R. Farrell J. Zaunders IM. Poynten L. Anderson L. Evans |
| author_facet | R. Farrell J. Zaunders IM. Poynten L. Anderson L. Evans |
| author_sort | R. Farrell |
| collection | DOAJ |
| description | This is the first report describing detailed T cell responses to viral-like proteins contained in an HPV specific vaccine given in combination with Imiquimod for treatment of persistent VAIN2/3. We postulate that stimulation of the innate immune system with Imiquimod and the specific CD4 and CD8T cell responses following HPV vaccination with Gardasil9@ combined to induce clinical remission in a woman with treatment-refractory disease. |
| first_indexed | 2024-03-07T19:09:10Z |
| format | Article |
| id | doaj.art-401a59962a6a4c96adfb68303426e94b |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-04-24T16:30:17Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-401a59962a6a4c96adfb68303426e94b2024-03-30T04:39:24ZengElsevierGynecologic Oncology Reports2352-57892024-04-0152101350Concurrent nonavalent human papillomavirus (HPV) vaccination and immune stimulation with imiquimod to treat recalcitrant HPV-associated high grade vaginal intra-epithelial neoplasiaR. Farrell0J. Zaunders1IM. Poynten2L. Anderson3L. Evans4Chris O'Brien Lifehouse Hospital, Camperdown, Sydney, New South Wales 2050, Australia; Sydney Medical School, University of Sydney, New South Wales 2006, Australia; Corresponding author at: ChrisO'Brien Lifehouse Hospital, Camperdown, Sydney, New South Wales 2050, Australia.NSW State Reference Labaoratory for HIV, Centre for Applied Medical Research, St Vincents Hospital, New South Wales, Australia; HIV Epidemiology and Prevention Program, The Kirby Institute, University of NSW Kensington, Sydney, New South Wales 2052, AustraliaHIV Epidemiology and Prevention Program, The Kirby Institute, University of NSW Kensington, Sydney, New South Wales 2052, AustraliaSydney Medical School, University of Sydney, New South Wales 2006, Australia; NSW Health Pathology, Royal Prince Alfred Hospital, Camperdown, Sydney, New South Wales 2050, AustraliaUniversity of NSW Kensington, Sydney, New South Wales 2052, Australia; Department of Clinical Immunology, Allergy and HIV, Liverpool Hospital, South Western Sydney Local Health District, Liverpool Sydney, New South Wales 2170, AustraliaThis is the first report describing detailed T cell responses to viral-like proteins contained in an HPV specific vaccine given in combination with Imiquimod for treatment of persistent VAIN2/3. We postulate that stimulation of the innate immune system with Imiquimod and the specific CD4 and CD8T cell responses following HPV vaccination with Gardasil9@ combined to induce clinical remission in a woman with treatment-refractory disease.http://www.sciencedirect.com/science/article/pii/S2352578924000298Human papillomavirus (HPV)Vaginal intraepitheial neoplasia (VAIN)ImiquimodHPV vaccine |
| spellingShingle | R. Farrell J. Zaunders IM. Poynten L. Anderson L. Evans Concurrent nonavalent human papillomavirus (HPV) vaccination and immune stimulation with imiquimod to treat recalcitrant HPV-associated high grade vaginal intra-epithelial neoplasia Gynecologic Oncology Reports Human papillomavirus (HPV) Vaginal intraepitheial neoplasia (VAIN) Imiquimod HPV vaccine |
| title | Concurrent nonavalent human papillomavirus (HPV) vaccination and immune stimulation with imiquimod to treat recalcitrant HPV-associated high grade vaginal intra-epithelial neoplasia |
| title_full | Concurrent nonavalent human papillomavirus (HPV) vaccination and immune stimulation with imiquimod to treat recalcitrant HPV-associated high grade vaginal intra-epithelial neoplasia |
| title_fullStr | Concurrent nonavalent human papillomavirus (HPV) vaccination and immune stimulation with imiquimod to treat recalcitrant HPV-associated high grade vaginal intra-epithelial neoplasia |
| title_full_unstemmed | Concurrent nonavalent human papillomavirus (HPV) vaccination and immune stimulation with imiquimod to treat recalcitrant HPV-associated high grade vaginal intra-epithelial neoplasia |
| title_short | Concurrent nonavalent human papillomavirus (HPV) vaccination and immune stimulation with imiquimod to treat recalcitrant HPV-associated high grade vaginal intra-epithelial neoplasia |
| title_sort | concurrent nonavalent human papillomavirus hpv vaccination and immune stimulation with imiquimod to treat recalcitrant hpv associated high grade vaginal intra epithelial neoplasia |
| topic | Human papillomavirus (HPV) Vaginal intraepitheial neoplasia (VAIN) Imiquimod HPV vaccine |
| url | http://www.sciencedirect.com/science/article/pii/S2352578924000298 |
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