Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus.

Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus.

Mature microRNAs (miRNAs), derived through cleavage of pre-miRNAs by the Dicer1 enzyme, regulate protein expression in many cell-types including cells in the pancreatic islets of Langerhans. To investigate the importance of miRNAs in mouse insulin secreting β-cells, we have generated mice with a β-c...

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Main Authors: Martins Kalis, Caroline Bolmeson, Jonathan L S Esguerra, Shashank Gupta, Anna Edlund, Neivis Tormo-Badia, Dina Speidel, Dan Holmberg, Sofia Mayans, Nelson K S Khoo, Anna Wendt, Lena Eliasson, Corrado M Cilio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3246465?pdf=render

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