Suppression of Hypertrophy During in vitro Chondrogenesis of Cocultures of Human Mesenchymal Stem Cells and Nasal Chondrocytes Correlates With Lack of in vivo Calcification and Vascular Invasion

Suppression of Hypertrophy During in vitro Chondrogenesis of Cocultures of Human Mesenchymal Stem Cells and Nasal Chondrocytes Correlates With Lack of in vivo Calcification and Vascular Invasion

ObjectiveHuman nasal septal chondrocytes (NC) are a promising minimally invasive derivable chondrogenic cell source for cartilage repair. However, the quality of NC-derived cartilage is variable between donors. Coculture of NC with mesenchymal stem cells (MSCs) mitigates the variability but with und...

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Bibliographic Details
Main Authors: Matthew Anderson-Baron, Yan Liang, Melanie Kunze, Aillette Mulet-Sierra, Martin Osswald, Khalid Ansari, Hadi Seikaly, Adetola B. Adesida
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
cartilage
cocultures
human mesenchymal stem cells
hypertrophic chondrogenesis
human nasal chondrocytes
xenograft
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2020.572356/full

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