The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus

The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus

Activation of the DNA-dependent innate immune pathway plays a pivotal role in the host defense against poxvirus. Cyclic GMP-AMP synthase (cGAS) is a key cytosolic DNA sensor that produces the cyclic dinucleotide cGMP-AMP (cGAMP) upon activation, which triggers stimulator of interferon genes (STING),...

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Bibliographic Details
Main Authors: Wen-Yu Cheng, Xiao-Bing He, Huai-Jie Jia, Guo-Hua Chen, Qi-Wang Jin, Zhao-Lin Long, Zhi-Zhong Jing
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
innate immunity
cGas
Sting
type I interferon
ectromelia virus
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01297/full

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