Multiple Myeloma as the Underlying Cause of Thrombotic Microangiopathy Leading to Acute Kidney Injury: Revisiting a Very Rare Entity
Thrombotic microangiopathy (TMA) describes a pathological process of microvascular thrombosis, consumptive thrombocytopenia, and microangiopathic hemolytic anemia, leading to end-organ ischemia and infarction, affecting particularly the kidney and brain. TMA is a pathological feature of a number of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-09-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/2324709617732797 |
| _version_ | 1818153630116610048 |
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| author | Savneek Chugh MD Asim Kichloo MD Firas Jafri MD Liga Yusvirazi MD Robert Lerner MD |
| author_facet | Savneek Chugh MD Asim Kichloo MD Firas Jafri MD Liga Yusvirazi MD Robert Lerner MD |
| author_sort | Savneek Chugh MD |
| collection | DOAJ |
| description | Thrombotic microangiopathy (TMA) describes a pathological process of microvascular thrombosis, consumptive thrombocytopenia, and microangiopathic hemolytic anemia, leading to end-organ ischemia and infarction, affecting particularly the kidney and brain. TMA is a pathological feature of a number of clinical disorders including thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, and atypical hemolytic uremic syndrome. Rare but important, TMA may also occur in malignancy, connective tissue disease, malignant hypertension, and renal transplantation (rejection or drug toxicity). We present a very rare case where the patient developed acute kidney injury from TMA but found to have multiple myeloma as the possible underlying etiology. |
| first_indexed | 2024-12-11T14:13:40Z |
| format | Article |
| id | doaj.art-401f7c1341fb4872a749a60272ae1c2b |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-12-11T14:13:40Z |
| publishDate | 2017-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-401f7c1341fb4872a749a60272ae1c2b2022-12-22T01:03:16ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962017-09-01510.1177/2324709617732797Multiple Myeloma as the Underlying Cause of Thrombotic Microangiopathy Leading to Acute Kidney Injury: Revisiting a Very Rare EntitySavneek Chugh MD0Asim Kichloo MD1Firas Jafri MD2Liga Yusvirazi MD3Robert Lerner MD4New York Medical College, Valhalla, NY, USACentral Michigan University, St Mary’s Hospital, Saginaw, MI, USANew York Medical College, Valhalla, NY, USANew York Medical College, Valhalla, NY, USANew York Medical College, Valhalla, NY, USAThrombotic microangiopathy (TMA) describes a pathological process of microvascular thrombosis, consumptive thrombocytopenia, and microangiopathic hemolytic anemia, leading to end-organ ischemia and infarction, affecting particularly the kidney and brain. TMA is a pathological feature of a number of clinical disorders including thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, and atypical hemolytic uremic syndrome. Rare but important, TMA may also occur in malignancy, connective tissue disease, malignant hypertension, and renal transplantation (rejection or drug toxicity). We present a very rare case where the patient developed acute kidney injury from TMA but found to have multiple myeloma as the possible underlying etiology.https://doi.org/10.1177/2324709617732797 |
| spellingShingle | Savneek Chugh MD Asim Kichloo MD Firas Jafri MD Liga Yusvirazi MD Robert Lerner MD Multiple Myeloma as the Underlying Cause of Thrombotic Microangiopathy Leading to Acute Kidney Injury: Revisiting a Very Rare Entity Journal of Investigative Medicine High Impact Case Reports |
| title | Multiple Myeloma as the Underlying Cause of Thrombotic Microangiopathy Leading to Acute Kidney Injury: Revisiting a Very Rare Entity |
| title_full | Multiple Myeloma as the Underlying Cause of Thrombotic Microangiopathy Leading to Acute Kidney Injury: Revisiting a Very Rare Entity |
| title_fullStr | Multiple Myeloma as the Underlying Cause of Thrombotic Microangiopathy Leading to Acute Kidney Injury: Revisiting a Very Rare Entity |
| title_full_unstemmed | Multiple Myeloma as the Underlying Cause of Thrombotic Microangiopathy Leading to Acute Kidney Injury: Revisiting a Very Rare Entity |
| title_short | Multiple Myeloma as the Underlying Cause of Thrombotic Microangiopathy Leading to Acute Kidney Injury: Revisiting a Very Rare Entity |
| title_sort | multiple myeloma as the underlying cause of thrombotic microangiopathy leading to acute kidney injury revisiting a very rare entity |
| url | https://doi.org/10.1177/2324709617732797 |
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