Refractory Cryptococcus neoformans Meningoencephalitis in an Immunocompetent Patient: Paradoxical Antifungal Therapy-Induced Clinical Deterioration Related to an Immune Response to Cryptococcal Organisms

Refractory Cryptococcus neoformans Meningoencephalitis in an Immunocompetent Patient: Paradoxical Antifungal Therapy-Induced Clinical Deterioration Related to an Immune Response to Cryptococcal Organisms

We present a case of refractory Cryptococcus neoformans meningoencephalitis in an immunocompetent woman. Her clinical symptoms did not improve with 6 months of antifungal therapy, and MRI abnormalities, indicating severe meningeal and cerebral inflammation, persisted despite a decreasing cryptococca...

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Bibliographic Details
Main Authors: Hideto Nakajima, Ayami Takayama, Yohei Fujiki, Takumi Ito, Haruko Kitaoka
Format: Article
Language:English
Published: Karger Publishers 2015-10-01
Series:Case Reports in Neurology
Subjects:
Paradoxical antifungal therapy-induced clinical deterioration
Cryptococcal meningoencephalitis
Corticosteroid
Cryptococcus neoformans
Immunocompetent host
Cryptococcal antigen titer
Online Access:http://www.karger.com/Article/FullText/440948

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