Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapy
Matrix metalloproteinases (MMPs), a class of zinc-contained endopeptidases, are closely involved in tumor growth, infiltration, metastasis, and angiogenesis. By virtue of the specifically enzymatic hydrolysis, MMPs have been widely used to turn on imaging and/or therapy function of elaborately desig...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-09-01
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| Series: | Reviews in Analytical Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/revac-2022-0044 |
| _version_ | 1797998569192423424 |
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| author | Wang Qiuye Cui Haijing Gan Ning Ma Xuehua Ren Wenzhi Wu Aiguo |
| author_facet | Wang Qiuye Cui Haijing Gan Ning Ma Xuehua Ren Wenzhi Wu Aiguo |
| author_sort | Wang Qiuye |
| collection | DOAJ |
| description | Matrix metalloproteinases (MMPs), a class of zinc-contained endopeptidases, are closely involved in tumor growth, infiltration, metastasis, and angiogenesis. By virtue of the specifically enzymatic hydrolysis, MMPs have been widely used to turn on imaging and/or therapy function of elaborately designed enzyme-responsive nanoprobes, which is expected to realize precise diagnosis and treatment of cancer. This review systematically summarizes the classifications of MMPs, their substrates and recognized sequences, and overexpressed tumor types. The advances of MMPs-responsive nanoprobes for cancer diagnosis and therapy are focused, including trigger mechanism, design principle, and various imaging or therapy modes. Finally, this review analyzes the challenges of MMPs-responsive nanoprobes in clinical application, and provides constructive opinions for future study. |
| first_indexed | 2024-04-11T10:50:51Z |
| format | Article |
| id | doaj.art-402126a576e441ac945b0231206d710e |
| institution | Directory Open Access Journal |
| issn | 2191-0189 |
| language | English |
| last_indexed | 2024-04-11T10:50:51Z |
| publishDate | 2022-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Reviews in Analytical Chemistry |
| spelling | doaj.art-402126a576e441ac945b0231206d710e2022-12-22T04:28:55ZengDe GruyterReviews in Analytical Chemistry2191-01892022-09-0141119821610.1515/revac-2022-0044Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapyWang Qiuye0Cui Haijing1Gan Ning2Ma Xuehua3Ren Wenzhi4Wu Aiguo5School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 ZhongGuan West Road, Ningbo 315201, ChinaSchool of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 ZhongGuan West Road, Ningbo 315201, ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 ZhongGuan West Road, Ningbo 315201, ChinaCixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 ZhongGuan West Road, Ningbo 315201, ChinaMatrix metalloproteinases (MMPs), a class of zinc-contained endopeptidases, are closely involved in tumor growth, infiltration, metastasis, and angiogenesis. By virtue of the specifically enzymatic hydrolysis, MMPs have been widely used to turn on imaging and/or therapy function of elaborately designed enzyme-responsive nanoprobes, which is expected to realize precise diagnosis and treatment of cancer. This review systematically summarizes the classifications of MMPs, their substrates and recognized sequences, and overexpressed tumor types. The advances of MMPs-responsive nanoprobes for cancer diagnosis and therapy are focused, including trigger mechanism, design principle, and various imaging or therapy modes. Finally, this review analyzes the challenges of MMPs-responsive nanoprobes in clinical application, and provides constructive opinions for future study.https://doi.org/10.1515/revac-2022-0044matrix metalloproteinasesenzyme-responsivecancerdiagnosistherapy |
| spellingShingle | Wang Qiuye Cui Haijing Gan Ning Ma Xuehua Ren Wenzhi Wu Aiguo Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapy Reviews in Analytical Chemistry matrix metalloproteinases enzyme-responsive cancer diagnosis therapy |
| title | Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapy |
| title_full | Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapy |
| title_fullStr | Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapy |
| title_full_unstemmed | Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapy |
| title_short | Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapy |
| title_sort | recent advances in matrix metalloproteinases responsive nanoprobes for cancer diagnosis and therapy |
| topic | matrix metalloproteinases enzyme-responsive cancer diagnosis therapy |
| url | https://doi.org/10.1515/revac-2022-0044 |
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