Association between Inflammation and Thrombotic Pathway Link with Pathogenesis of Depression and Anxiety in SLE Patients
As a complication of systemic lupus erythematosus (SLE), the neuropsychiatric form may manifest with neurological and psychiatric symptoms. Diagnosing neuropsychiatric SLE can be challenging due to the heterogeneity of this disease manifestation and the possibilities of investigation. This research...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/3/567 |
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| author | Liliana Duca Nadinne Roman Andreea Teodorescu Petru Ifteni |
| author_facet | Liliana Duca Nadinne Roman Andreea Teodorescu Petru Ifteni |
| author_sort | Liliana Duca |
| collection | DOAJ |
| description | As a complication of systemic lupus erythematosus (SLE), the neuropsychiatric form may manifest with neurological and psychiatric symptoms. Diagnosing neuropsychiatric SLE can be challenging due to the heterogeneity of this disease manifestation and the possibilities of investigation. This research aims to identify the possible associations between inflammation and thrombotic biomarkers alongside anxiety and/or depression manifestations in SLE patients. A group of 65 outpatients were investigated regarding the levels of depression, anxiety, disability, quality of life and other specific serum biomarkers linked with inflammation or coagulopathies. The results showed severe depression in eight participants, moderate depression in 22 (33.85%), and 26 (40%) subjects with mild depression. Anxiety was more prevalent within 64 participants (98.46%), while a degree of disability was reported by 52 participants (80%). Quality of life evaluated by EQ5D revealed a medium value of 1.57, and EQ5D VAS health medium value was 57.95 and was correlated with anxiety. A strong positive correlation between depression, anxiety and antibodies associated with anti-cardiolipin and anti beta2 glycoprotein I antibodies, lupus anticoagulant, ICAM-1, low C4 a and anti-ribosomal P antibodies were identified. These data results suggest that autoimmune/inflammatory and ischemic/thrombotic pathways could contribute to depression and anxiety as neuropsychiatric SLE manifestations. |
| first_indexed | 2024-03-11T06:52:23Z |
| format | Article |
| id | doaj.art-4021ff9bf7274874b9f1e9450712c94c |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T06:52:23Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-4021ff9bf7274874b9f1e9450712c94c2023-11-17T09:53:07ZengMDPI AGBiomolecules2218-273X2023-03-0113356710.3390/biom13030567Association between Inflammation and Thrombotic Pathway Link with Pathogenesis of Depression and Anxiety in SLE PatientsLiliana Duca0Nadinne Roman1Andreea Teodorescu2Petru Ifteni3Faculty of Medicine, Transilvania University of Braşov, 500036 Braşov, RomaniaFaculty of Medicine, Transilvania University of Braşov, 500036 Braşov, RomaniaFaculty of Medicine, Transilvania University of Braşov, 500036 Braşov, RomaniaFaculty of Medicine, Transilvania University of Braşov, 500036 Braşov, RomaniaAs a complication of systemic lupus erythematosus (SLE), the neuropsychiatric form may manifest with neurological and psychiatric symptoms. Diagnosing neuropsychiatric SLE can be challenging due to the heterogeneity of this disease manifestation and the possibilities of investigation. This research aims to identify the possible associations between inflammation and thrombotic biomarkers alongside anxiety and/or depression manifestations in SLE patients. A group of 65 outpatients were investigated regarding the levels of depression, anxiety, disability, quality of life and other specific serum biomarkers linked with inflammation or coagulopathies. The results showed severe depression in eight participants, moderate depression in 22 (33.85%), and 26 (40%) subjects with mild depression. Anxiety was more prevalent within 64 participants (98.46%), while a degree of disability was reported by 52 participants (80%). Quality of life evaluated by EQ5D revealed a medium value of 1.57, and EQ5D VAS health medium value was 57.95 and was correlated with anxiety. A strong positive correlation between depression, anxiety and antibodies associated with anti-cardiolipin and anti beta2 glycoprotein I antibodies, lupus anticoagulant, ICAM-1, low C4 a and anti-ribosomal P antibodies were identified. These data results suggest that autoimmune/inflammatory and ischemic/thrombotic pathways could contribute to depression and anxiety as neuropsychiatric SLE manifestations.https://www.mdpi.com/2218-273X/13/3/567systemic lupus erythematosusdepressionanxietyinflammationthrombotic |
| spellingShingle | Liliana Duca Nadinne Roman Andreea Teodorescu Petru Ifteni Association between Inflammation and Thrombotic Pathway Link with Pathogenesis of Depression and Anxiety in SLE Patients Biomolecules systemic lupus erythematosus depression anxiety inflammation thrombotic |
| title | Association between Inflammation and Thrombotic Pathway Link with Pathogenesis of Depression and Anxiety in SLE Patients |
| title_full | Association between Inflammation and Thrombotic Pathway Link with Pathogenesis of Depression and Anxiety in SLE Patients |
| title_fullStr | Association between Inflammation and Thrombotic Pathway Link with Pathogenesis of Depression and Anxiety in SLE Patients |
| title_full_unstemmed | Association between Inflammation and Thrombotic Pathway Link with Pathogenesis of Depression and Anxiety in SLE Patients |
| title_short | Association between Inflammation and Thrombotic Pathway Link with Pathogenesis of Depression and Anxiety in SLE Patients |
| title_sort | association between inflammation and thrombotic pathway link with pathogenesis of depression and anxiety in sle patients |
| topic | systemic lupus erythematosus depression anxiety inflammation thrombotic |
| url | https://www.mdpi.com/2218-273X/13/3/567 |
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