Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends
During peripheral nerve transposition repair, if the diameter difference between transposed nerves is large or multiple distal nerves must be repaired at the same time, traditional epineurial neurorrhaphy has the problem of high tension at the suture site, which may even lead to the failure of nerve...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=4;spage=706;epage=712;aulast=Kou |
| _version_ | 1818137183729483776 |
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| author | Yu-Hui Kou You-Lai Yu Ya-Jun Zhang Na Han Xiao-Feng Yin Yu-Song Yuan Fei Yu Dian-Ying Zhang Pei-Xun Zhang Bao-Guo Jiang |
| author_facet | Yu-Hui Kou You-Lai Yu Ya-Jun Zhang Na Han Xiao-Feng Yin Yu-Song Yuan Fei Yu Dian-Ying Zhang Pei-Xun Zhang Bao-Guo Jiang |
| author_sort | Yu-Hui Kou |
| collection | DOAJ |
| description | During peripheral nerve transposition repair, if the diameter difference between transposed nerves is large or multiple distal nerves must be repaired at the same time, traditional epineurial neurorrhaphy has the problem of high tension at the suture site, which may even lead to the failure of nerve suture. We investigated whether a small gap bio-sleeve suture with different inner diameters at both ends can be used to repair a 2-mm tibial nerve defect by proximal transposition of the common peroneal nerve in rats and compared the results with the repair seen after epineurial neurorrhaphy. Three months after surgery, neurological function, nerve regeneration, and recovery of nerve innervation muscle were assessed using the tibial nerve function index, neuroelectrophysiological testing, muscle biomechanics and wet weight measurement, osmic acid staining, and hematoxylin-eosin staining. There was no obvious inflammatory reaction and neuroma formation in the tibial nerve after repair by the small gap bio-sleeve suture with different inner diameters at both ends. The conduction velocity, muscle strength, wet muscle weight, cross-sectional area of muscle fibers, and the number of new myelinated nerve fibers in the bio-sleeve suture group were similar to those in the epineurial neurorrhaphy group. Our findings indicate that small gap bio-sleeve suture with different inner diameters at both ends can achieve surgical suture between nerves of different diameters and promote regeneration and functional recovery of injured peripheral nerves. |
| first_indexed | 2024-12-11T09:52:15Z |
| format | Article |
| id | doaj.art-402292dc2438406c83863a2f111a6bfd |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-11T09:52:15Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-402292dc2438406c83863a2f111a6bfd2022-12-22T01:12:22ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742019-01-0114470671210.4103/1673-5374.247475Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both endsYu-Hui KouYou-Lai YuYa-Jun ZhangNa HanXiao-Feng YinYu-Song YuanFei YuDian-Ying ZhangPei-Xun ZhangBao-Guo JiangDuring peripheral nerve transposition repair, if the diameter difference between transposed nerves is large or multiple distal nerves must be repaired at the same time, traditional epineurial neurorrhaphy has the problem of high tension at the suture site, which may even lead to the failure of nerve suture. We investigated whether a small gap bio-sleeve suture with different inner diameters at both ends can be used to repair a 2-mm tibial nerve defect by proximal transposition of the common peroneal nerve in rats and compared the results with the repair seen after epineurial neurorrhaphy. Three months after surgery, neurological function, nerve regeneration, and recovery of nerve innervation muscle were assessed using the tibial nerve function index, neuroelectrophysiological testing, muscle biomechanics and wet weight measurement, osmic acid staining, and hematoxylin-eosin staining. There was no obvious inflammatory reaction and neuroma formation in the tibial nerve after repair by the small gap bio-sleeve suture with different inner diameters at both ends. The conduction velocity, muscle strength, wet muscle weight, cross-sectional area of muscle fibers, and the number of new myelinated nerve fibers in the bio-sleeve suture group were similar to those in the epineurial neurorrhaphy group. Our findings indicate that small gap bio-sleeve suture with different inner diameters at both ends can achieve surgical suture between nerves of different diameters and promote regeneration and functional recovery of injured peripheral nerves.http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=4;spage=706;epage=712;aulast=Kounerve regeneration; bio-sleeve; small gap; sleeve suture; nerve transposition; nerve defect; nerve conduit; nerve reinnervation; peripheral nerve; neural regeneration |
| spellingShingle | Yu-Hui Kou You-Lai Yu Ya-Jun Zhang Na Han Xiao-Feng Yin Yu-Song Yuan Fei Yu Dian-Ying Zhang Pei-Xun Zhang Bao-Guo Jiang Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends Neural Regeneration Research nerve regeneration; bio-sleeve; small gap; sleeve suture; nerve transposition; nerve defect; nerve conduit; nerve reinnervation; peripheral nerve; neural regeneration |
| title | Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends |
| title_full | Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends |
| title_fullStr | Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends |
| title_full_unstemmed | Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends |
| title_short | Repair of peripheral nerve defects by nerve transposition using small gap bio-sleeve suture with different inner diameters at both ends |
| title_sort | repair of peripheral nerve defects by nerve transposition using small gap bio sleeve suture with different inner diameters at both ends |
| topic | nerve regeneration; bio-sleeve; small gap; sleeve suture; nerve transposition; nerve defect; nerve conduit; nerve reinnervation; peripheral nerve; neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=4;spage=706;epage=712;aulast=Kou |
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