The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes
Stem cell therapy using islet-like insulin-producing cells derived from human pluripotent stem cells has the potential to allow patients with type 1 diabetes to withdraw from insulin therapy. However, several issues exist regarding the use of stem cell therapy to treat type 1 diabetes. In this revie...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/7/1589 |
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| author | Ryota Inoue Kuniyuki Nishiyama Jinghe Li Daisuke Miyashita Masato Ono Yasuo Terauchi Jun Shirakawa |
| author_facet | Ryota Inoue Kuniyuki Nishiyama Jinghe Li Daisuke Miyashita Masato Ono Yasuo Terauchi Jun Shirakawa |
| author_sort | Ryota Inoue |
| collection | DOAJ |
| description | Stem cell therapy using islet-like insulin-producing cells derived from human pluripotent stem cells has the potential to allow patients with type 1 diabetes to withdraw from insulin therapy. However, several issues exist regarding the use of stem cell therapy to treat type 1 diabetes. In this review, we will focus on the following topics: (1) autoimmune responses during the autologous transplantation of stem cell-derived islet cells, (2) a comparison of stem cell therapy with insulin injection therapy, (3) the impact of the islet microenvironment on stem cell-derived islet cells, and (4) the cost-effectiveness of stem cell-derived islet cell transplantation. Based on these various viewpoints, we will discuss what is required to perform stem cell therapy for patients with type 1 diabetes. |
| first_indexed | 2024-03-10T10:06:25Z |
| format | Article |
| id | doaj.art-4026761c64a448aeabd8c2257b2ff550 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:06:25Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4026761c64a448aeabd8c2257b2ff5502023-11-22T01:30:53ZengMDPI AGCells2073-44092021-06-01107158910.3390/cells10071589The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 DiabetesRyota Inoue0Kuniyuki Nishiyama1Jinghe Li2Daisuke Miyashita3Masato Ono4Yasuo Terauchi5Jun Shirakawa6Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi 371-8512, JapanLaboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi 371-8512, JapanLaboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi 371-8512, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama 236-0004, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama 236-0004, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama City University, Yokohama 236-0004, JapanLaboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi 371-8512, JapanStem cell therapy using islet-like insulin-producing cells derived from human pluripotent stem cells has the potential to allow patients with type 1 diabetes to withdraw from insulin therapy. However, several issues exist regarding the use of stem cell therapy to treat type 1 diabetes. In this review, we will focus on the following topics: (1) autoimmune responses during the autologous transplantation of stem cell-derived islet cells, (2) a comparison of stem cell therapy with insulin injection therapy, (3) the impact of the islet microenvironment on stem cell-derived islet cells, and (4) the cost-effectiveness of stem cell-derived islet cell transplantation. Based on these various viewpoints, we will discuss what is required to perform stem cell therapy for patients with type 1 diabetes.https://www.mdpi.com/2073-4409/10/7/1589diabetestype 1 diabetesstem cell therapypancreatic β-cell |
| spellingShingle | Ryota Inoue Kuniyuki Nishiyama Jinghe Li Daisuke Miyashita Masato Ono Yasuo Terauchi Jun Shirakawa The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes Cells diabetes type 1 diabetes stem cell therapy pancreatic β-cell |
| title | The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes |
| title_full | The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes |
| title_fullStr | The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes |
| title_full_unstemmed | The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes |
| title_short | The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes |
| title_sort | feasibility and applicability of stem cell therapy for the cure of type 1 diabetes |
| topic | diabetes type 1 diabetes stem cell therapy pancreatic β-cell |
| url | https://www.mdpi.com/2073-4409/10/7/1589 |
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