Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population
Background: Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent. Objective: We examined the associations of G...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Science, Yazd, Iran
2016-04-01
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| Series: | Iranian Journal of Reproductive Medicine |
| Online Access: | http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1903/967 |
| _version_ | 1811201904452042752 |
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| author | Mina Hassani Kioomars Saliminejad Masood Heidarizadeh Koorosh Kamali Toktam Memariani Hamid Reza Khorram Khorshid |
| author_facet | Mina Hassani Kioomars Saliminejad Masood Heidarizadeh Koorosh Kamali Toktam Memariani Hamid Reza Khorram Khorshid |
| author_sort | Mina Hassani |
| collection | DOAJ |
| description | Background: Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent.
Objective: We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G polymorphisms with endometriosis in an Iranian population.
Materials and Methods: In this case-control study, 151 women with diagnosis of endometriosis and 156 normal healthy women as control group were included. The genotyping was determined using multiplex PCR and PCR- RFLP methods.
Results: The GSTM1 null genotype was significantly higher (p=0.027) in the cases (7.3%) than the control group (1.3%). There was no significant difference between the frequency of GSTT1 genotypes between the cases and controls. The GSTP1 313 AG genotype was significantly lower (p=0.048) in the case (33.1%) than the control group (44.4%).
Conclusion: Our results showed that GSTM1 and GSTP1 polymorphisms may be associated with susceptibility of endometriosis in Iranian women.
Key |
| first_indexed | 2024-04-12T02:29:46Z |
| format | Article |
| id | doaj.art-4027907d61f04ac8bf374a364f1cd836 |
| institution | Directory Open Access Journal |
| issn | 1680-6433 2008-2177 |
| language | English |
| last_indexed | 2024-04-12T02:29:46Z |
| publishDate | 2016-04-01 |
| publisher | Shahid Sadoughi University of Medical Science, Yazd, Iran |
| record_format | Article |
| series | Iranian Journal of Reproductive Medicine |
| spelling | doaj.art-4027907d61f04ac8bf374a364f1cd8362022-12-22T03:51:50ZengShahid Sadoughi University of Medical Science, Yazd, IranIranian Journal of Reproductive Medicine1680-64332008-21772016-04-01144241246Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian populationMina Hassani0Kioomars Saliminejad1Masood Heidarizadeh2Koorosh Kamali3Toktam Memariani4Hamid Reza Khorram Khorshid5Department of Biology, Faculty of Science, University of Kurdistan, Sanandaj, Iran.Reproductive Biotechnology Research Center, Avicenna Research Institute (ACECR), Tehran, IranDepartment of Biology, Faculty of Science, University of Kurdistan, Sanandaj, IranToktam MemarianiCentral Research Lab, North Khorasan University of Medical Sciences, Bojnurd, IranGenetic Research Center, University of Social Welfare and Rehabilitation Science, Tehran, Iran.Background: Endometriosis influenced by both genetic and environmental factors. Associations of glutathione S-transferases (GSTs) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent. Objective: We examined the associations of GSTM1 and GSTT1 null genotypes and GSTP1 313 A/G polymorphisms with endometriosis in an Iranian population. Materials and Methods: In this case-control study, 151 women with diagnosis of endometriosis and 156 normal healthy women as control group were included. The genotyping was determined using multiplex PCR and PCR- RFLP methods. Results: The GSTM1 null genotype was significantly higher (p=0.027) in the cases (7.3%) than the control group (1.3%). There was no significant difference between the frequency of GSTT1 genotypes between the cases and controls. The GSTP1 313 AG genotype was significantly lower (p=0.048) in the case (33.1%) than the control group (44.4%). Conclusion: Our results showed that GSTM1 and GSTP1 polymorphisms may be associated with susceptibility of endometriosis in Iranian women. Keyhttp://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1903/967 |
| spellingShingle | Mina Hassani Kioomars Saliminejad Masood Heidarizadeh Koorosh Kamali Toktam Memariani Hamid Reza Khorram Khorshid Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population Iranian Journal of Reproductive Medicine |
| title | Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population |
| title_full | Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population |
| title_fullStr | Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population |
| title_full_unstemmed | Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population |
| title_short | Association study of Glutathione S-Transferase polymorphisms and risk of endometriosis in an Iranian population |
| title_sort | association study of glutathione s transferase polymorphisms and risk of endometriosis in an iranian population |
| url | http://www.ssu.ac.ir/ijrm/index.php/ijrm/article/view/1903/967 |
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