Identification of putative calorie restriction mimetics using mammalian gene expression profiles
Obesity is a risk factor for cardiovascular diseases, diabetes and cancer. In theory, the obesity problem could be solved by the adherence to a calorie-restricted diet, but that is not generally achieved in practice. An alternative is a pharmacological approach, using compounds that trigger the same...
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| Format: | Article |
| Language: | English |
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The Royal Society
2020-09-01
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| Series: | Open Biology |
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| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200158 |
| _version_ | 1818846444405129216 |
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| author | Alexei Vazquez |
| author_facet | Alexei Vazquez |
| author_sort | Alexei Vazquez |
| collection | DOAJ |
| description | Obesity is a risk factor for cardiovascular diseases, diabetes and cancer. In theory, the obesity problem could be solved by the adherence to a calorie-restricted diet, but that is not generally achieved in practice. An alternative is a pharmacological approach, using compounds that trigger the same metabolic changes associated with calorie restriction. Here, I expand in the pharmacological direction by identifying compounds that induce liver gene signature profiles that mimic those induced by calorie restriction. Using gene expression profiles from mice and rat, I identify corticosteroids, PPAR agonists and some antibacterial/antifungal as candidate compounds mimicking the response to calorie restriction in the liver gene signatures. |
| first_indexed | 2024-12-19T05:45:39Z |
| format | Article |
| id | doaj.art-4029b700e59b47549f97264417d07760 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-19T05:45:39Z |
| publishDate | 2020-09-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-4029b700e59b47549f97264417d077602022-12-21T20:33:52ZengThe Royal SocietyOpen Biology2046-24412020-09-0110910.1098/rsob.200158200158Identification of putative calorie restriction mimetics using mammalian gene expression profilesAlexei VazquezObesity is a risk factor for cardiovascular diseases, diabetes and cancer. In theory, the obesity problem could be solved by the adherence to a calorie-restricted diet, but that is not generally achieved in practice. An alternative is a pharmacological approach, using compounds that trigger the same metabolic changes associated with calorie restriction. Here, I expand in the pharmacological direction by identifying compounds that induce liver gene signature profiles that mimic those induced by calorie restriction. Using gene expression profiles from mice and rat, I identify corticosteroids, PPAR agonists and some antibacterial/antifungal as candidate compounds mimicking the response to calorie restriction in the liver gene signatures.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200158obesitycalorie restrictiongene signaturescorticosteroidsppar agonistsantibacterial–antifungal |
| spellingShingle | Alexei Vazquez Identification of putative calorie restriction mimetics using mammalian gene expression profiles Open Biology obesity calorie restriction gene signatures corticosteroids ppar agonists antibacterial–antifungal |
| title | Identification of putative calorie restriction mimetics using mammalian gene expression profiles |
| title_full | Identification of putative calorie restriction mimetics using mammalian gene expression profiles |
| title_fullStr | Identification of putative calorie restriction mimetics using mammalian gene expression profiles |
| title_full_unstemmed | Identification of putative calorie restriction mimetics using mammalian gene expression profiles |
| title_short | Identification of putative calorie restriction mimetics using mammalian gene expression profiles |
| title_sort | identification of putative calorie restriction mimetics using mammalian gene expression profiles |
| topic | obesity calorie restriction gene signatures corticosteroids ppar agonists antibacterial–antifungal |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200158 |
| work_keys_str_mv | AT alexeivazquez identificationofputativecalorierestrictionmimeticsusingmammaliangeneexpressionprofiles |