The photosensitizer-based therapies enhance the repairing of skin wounds
Wound repair remains a clinical challenge and bacterial infection is a common complication that may significantly delay healing. Therefore, proper and effective wound management is essential. The photosensitizer-based therapies mainly stimulate the photosensitizer to generate reactive oxygen species...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.915548/full |
| _version_ | 1828287559132774400 |
|---|---|
| author | Xiaoying Ning Gang He Gang He Weihui Zeng Yumin Xia |
| author_facet | Xiaoying Ning Gang He Gang He Weihui Zeng Yumin Xia |
| author_sort | Xiaoying Ning |
| collection | DOAJ |
| description | Wound repair remains a clinical challenge and bacterial infection is a common complication that may significantly delay healing. Therefore, proper and effective wound management is essential. The photosensitizer-based therapies mainly stimulate the photosensitizer to generate reactive oxygen species through appropriate excitation source irradiation, thereby killing pathogenic microorganisms. Moreover, they initiate local immune responses by inducing the recruitment of immune cells as well as the production of proinflammatory cytokines. In addition, these therapies can stimulate the proliferation, migration and differentiation of skin resident cells, and improve the deposition of extracellular matrix; subsequently, they promote the re-epithelialization, angiogenesis, and tissue remodeling. Studies in multiple animal models and human skin wounds have proved that the superior sterilization property and biological effects of photosensitizer-based therapies during different stages of wound repair. In this review, we summarize the recent advances in photosensitizer-based therapies for enhancing tissue regeneration, and suggest more effective therapeutics for patients with skin wounds. |
| first_indexed | 2024-04-13T09:49:17Z |
| format | Article |
| id | doaj.art-4029e5098745455f8b0b8ebd1b2e8073 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-13T09:49:17Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-4029e5098745455f8b0b8ebd1b2e80732022-12-22T02:51:37ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-08-01910.3389/fmed.2022.915548915548The photosensitizer-based therapies enhance the repairing of skin woundsXiaoying Ning0Gang He1Gang He2Weihui Zeng3Yumin Xia4Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaState Key Laboratory for Strength and Vibration of Mechanical Structures, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, ChinaXi’an Key Laboratory of Sustainable Energy Materials Chemistry, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaWound repair remains a clinical challenge and bacterial infection is a common complication that may significantly delay healing. Therefore, proper and effective wound management is essential. The photosensitizer-based therapies mainly stimulate the photosensitizer to generate reactive oxygen species through appropriate excitation source irradiation, thereby killing pathogenic microorganisms. Moreover, they initiate local immune responses by inducing the recruitment of immune cells as well as the production of proinflammatory cytokines. In addition, these therapies can stimulate the proliferation, migration and differentiation of skin resident cells, and improve the deposition of extracellular matrix; subsequently, they promote the re-epithelialization, angiogenesis, and tissue remodeling. Studies in multiple animal models and human skin wounds have proved that the superior sterilization property and biological effects of photosensitizer-based therapies during different stages of wound repair. In this review, we summarize the recent advances in photosensitizer-based therapies for enhancing tissue regeneration, and suggest more effective therapeutics for patients with skin wounds.https://www.frontiersin.org/articles/10.3389/fmed.2022.915548/fullphotosensitizer-based therapywound repairskinanti-infectionimmunomodulatory |
| spellingShingle | Xiaoying Ning Gang He Gang He Weihui Zeng Yumin Xia The photosensitizer-based therapies enhance the repairing of skin wounds Frontiers in Medicine photosensitizer-based therapy wound repair skin anti-infection immunomodulatory |
| title | The photosensitizer-based therapies enhance the repairing of skin wounds |
| title_full | The photosensitizer-based therapies enhance the repairing of skin wounds |
| title_fullStr | The photosensitizer-based therapies enhance the repairing of skin wounds |
| title_full_unstemmed | The photosensitizer-based therapies enhance the repairing of skin wounds |
| title_short | The photosensitizer-based therapies enhance the repairing of skin wounds |
| title_sort | photosensitizer based therapies enhance the repairing of skin wounds |
| topic | photosensitizer-based therapy wound repair skin anti-infection immunomodulatory |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.915548/full |
| work_keys_str_mv | AT xiaoyingning thephotosensitizerbasedtherapiesenhancetherepairingofskinwounds AT ganghe thephotosensitizerbasedtherapiesenhancetherepairingofskinwounds AT ganghe thephotosensitizerbasedtherapiesenhancetherepairingofskinwounds AT weihuizeng thephotosensitizerbasedtherapiesenhancetherepairingofskinwounds AT yuminxia thephotosensitizerbasedtherapiesenhancetherepairingofskinwounds AT xiaoyingning photosensitizerbasedtherapiesenhancetherepairingofskinwounds AT ganghe photosensitizerbasedtherapiesenhancetherepairingofskinwounds AT ganghe photosensitizerbasedtherapiesenhancetherepairingofskinwounds AT weihuizeng photosensitizerbasedtherapiesenhancetherepairingofskinwounds AT yuminxia photosensitizerbasedtherapiesenhancetherepairingofskinwounds |