The effects of postoperative treadmill exercise on rats with secondary lymphedema
Cancer-related lymphedema (LE) is often caused by radiotherapy and surgery such as lymph node dissection (LND). Previous studies have reported that exercise is beneficial to relieve LE, but the changes in the lymphatic system following exercise are still unclear. This study aimed to examine the chan...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204966/?tool=EBI |
| _version_ | 1797819805594550272 |
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| author | Sang Ah Kim Ma. Nessa Gelvosa Hwayeong Cheon Jae Yong Jeon |
| author_facet | Sang Ah Kim Ma. Nessa Gelvosa Hwayeong Cheon Jae Yong Jeon |
| author_sort | Sang Ah Kim |
| collection | DOAJ |
| description | Cancer-related lymphedema (LE) is often caused by radiotherapy and surgery such as lymph node dissection (LND). Previous studies have reported that exercise is beneficial to relieve LE, but the changes in the lymphatic system following exercise are still unclear. This study aimed to examine the changes in lymphatic drainage pathways over the exercise period and beneficial effects of exercise in rats with LE. Twelve rats were randomly allocated into exercise and control groups (EG and CG; n = 6 each). To obtain LE, inguinal and popliteal LND followed by 20 Gy irradiation was performed. Treadmill exercise was 30 minutes/day, 5 days/week over the four-week period. Consecutive indocyanine green (ICG) lymphography images were collected and classified into five patterns: i) linear; ii) splash; iii) stardust; iv) diffuse, and v) none. Ankle thickness was measured weekly. Histopathological evaluation was performed to examine the skin thickness, collagen area fraction (%) and lymphatic vessel density in harvested tissue. ICG lymphography exhibited more linear and splash patterns in the EG at week 3. The difference of swelling between both groups was significantly different at week 4 (p = 0.016). Histopathologic data revealed a thinner epidermis (p = 0.041) and dermis (p = 0.002), lower collagen area fraction (%, p = 0.002), and higher lymph vessel density (p = 0.002) in the EG than the CG. In conclusion, we found that postoperative exercise can facilitate improvement in lymphatic fluid retention in the lymphedema rat model, resulting in improvement of pathological conditions in the lymphatic system. |
| first_indexed | 2024-03-13T09:28:01Z |
| format | Article |
| id | doaj.art-402bd85583b5414c9deb6332ef0b0bcf |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-13T09:28:01Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-402bd85583b5414c9deb6332ef0b0bcf2023-05-26T05:31:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01185The effects of postoperative treadmill exercise on rats with secondary lymphedemaSang Ah KimMa. Nessa GelvosaHwayeong CheonJae Yong JeonCancer-related lymphedema (LE) is often caused by radiotherapy and surgery such as lymph node dissection (LND). Previous studies have reported that exercise is beneficial to relieve LE, but the changes in the lymphatic system following exercise are still unclear. This study aimed to examine the changes in lymphatic drainage pathways over the exercise period and beneficial effects of exercise in rats with LE. Twelve rats were randomly allocated into exercise and control groups (EG and CG; n = 6 each). To obtain LE, inguinal and popliteal LND followed by 20 Gy irradiation was performed. Treadmill exercise was 30 minutes/day, 5 days/week over the four-week period. Consecutive indocyanine green (ICG) lymphography images were collected and classified into five patterns: i) linear; ii) splash; iii) stardust; iv) diffuse, and v) none. Ankle thickness was measured weekly. Histopathological evaluation was performed to examine the skin thickness, collagen area fraction (%) and lymphatic vessel density in harvested tissue. ICG lymphography exhibited more linear and splash patterns in the EG at week 3. The difference of swelling between both groups was significantly different at week 4 (p = 0.016). Histopathologic data revealed a thinner epidermis (p = 0.041) and dermis (p = 0.002), lower collagen area fraction (%, p = 0.002), and higher lymph vessel density (p = 0.002) in the EG than the CG. In conclusion, we found that postoperative exercise can facilitate improvement in lymphatic fluid retention in the lymphedema rat model, resulting in improvement of pathological conditions in the lymphatic system.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204966/?tool=EBI |
| spellingShingle | Sang Ah Kim Ma. Nessa Gelvosa Hwayeong Cheon Jae Yong Jeon The effects of postoperative treadmill exercise on rats with secondary lymphedema PLoS ONE |
| title | The effects of postoperative treadmill exercise on rats with secondary lymphedema |
| title_full | The effects of postoperative treadmill exercise on rats with secondary lymphedema |
| title_fullStr | The effects of postoperative treadmill exercise on rats with secondary lymphedema |
| title_full_unstemmed | The effects of postoperative treadmill exercise on rats with secondary lymphedema |
| title_short | The effects of postoperative treadmill exercise on rats with secondary lymphedema |
| title_sort | effects of postoperative treadmill exercise on rats with secondary lymphedema |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204966/?tool=EBI |
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