Effect of <it>epimedium pubescen</it> flavonoid on bone mineral status and bone turnover in male rats chronically exposed to cigarette smoke
<p>Abstract</p> <p>Background</p> <p><it>Epimedii herba</it> is one of the most frequently used herbs in formulas that are prescribed for the treatment of osteoporosis in China and its main constituent is <it>Epimedium pubescen</it> flavonoid (EP...
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| Format: | Article |
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BMC
2012-06-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | http://www.biomedcentral.com/1471-2474/13/105 |
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| author | Gao Shu-guang Cheng Ling Li Kang-hua Liu Wen-He Xu Mai Jiang Wei Wei Li-Cheng Zhang Fang-jie Xiao Wen-feng Xiong Yi-lin Tian Jian Zeng Chao Sun Jin-peng Xie Qiang Lei Guang-hua |
| author_facet | Gao Shu-guang Cheng Ling Li Kang-hua Liu Wen-He Xu Mai Jiang Wei Wei Li-Cheng Zhang Fang-jie Xiao Wen-feng Xiong Yi-lin Tian Jian Zeng Chao Sun Jin-peng Xie Qiang Lei Guang-hua |
| author_sort | Gao Shu-guang |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p><it>Epimedii herba</it> is one of the most frequently used herbs in formulas that are prescribed for the treatment of osteoporosis in China and its main constituent is <it>Epimedium pubescen</it> flavonoid (EPF). However, it is unclear whether EPF during chronic exposure to cigarette smoke may have a protective influence on the skeleton. The present study investigated the effect of EPF on bone mineral status and bone turnover in a rat model of human relatively high exposure to cigarette smoke.</p> <p>Methods</p> <p>Fifty male Wistar rats were randomized into five groups: controls, passive smoking groups and passive smoking rats administered EPF at three dosage levels (75, 150 or 300 mg/kg/day) in drinking water for 4 months. A rat model of passive smoking was prepared by breeding male rats in a cigarette-smoking box. Bone mineral content (BMC), bone mineral density (BMD), bone turnover markers, bone histomorphometric parameters and biomechanical properties were examined.</p> <p>Results</p> <p>Smoke exposure decreased BMC and BMD, increased bone turnover (inhibited bone formation and stimulated its resorption), affected bone histomorphometry (increased trabecular separation and osteoclast surface per bone surface; decreased trabecular bone volume, trabecular thickness, trabecular number, cortical thickness, bone formation rate and osteoblast surface per bone surface), and reduced mechanical properties. EPF supplementation during cigarette smoke exposure prevented smoke-induced changes in bone mineral status and bone turnover.</p> <p>Conclusion</p> <p>The results suggest that EPF can prevent the adverse effects of smoke exposure on bone by stimulating bone formation and inhibiting bone turnover and bone resorption.</p> |
| first_indexed | 2024-12-11T14:46:07Z |
| format | Article |
| id | doaj.art-402ddbd6abec4498b8660ef020771be5 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-11T14:46:07Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-402ddbd6abec4498b8660ef020771be52022-12-22T01:01:41ZengBMCBMC Musculoskeletal Disorders1471-24742012-06-0113110510.1186/1471-2474-13-105Effect of <it>epimedium pubescen</it> flavonoid on bone mineral status and bone turnover in male rats chronically exposed to cigarette smokeGao Shu-guangCheng LingLi Kang-huaLiu Wen-HeXu MaiJiang WeiWei Li-ChengZhang Fang-jieXiao Wen-fengXiong Yi-linTian JianZeng ChaoSun Jin-pengXie QiangLei Guang-hua<p>Abstract</p> <p>Background</p> <p><it>Epimedii herba</it> is one of the most frequently used herbs in formulas that are prescribed for the treatment of osteoporosis in China and its main constituent is <it>Epimedium pubescen</it> flavonoid (EPF). However, it is unclear whether EPF during chronic exposure to cigarette smoke may have a protective influence on the skeleton. The present study investigated the effect of EPF on bone mineral status and bone turnover in a rat model of human relatively high exposure to cigarette smoke.</p> <p>Methods</p> <p>Fifty male Wistar rats were randomized into five groups: controls, passive smoking groups and passive smoking rats administered EPF at three dosage levels (75, 150 or 300 mg/kg/day) in drinking water for 4 months. A rat model of passive smoking was prepared by breeding male rats in a cigarette-smoking box. Bone mineral content (BMC), bone mineral density (BMD), bone turnover markers, bone histomorphometric parameters and biomechanical properties were examined.</p> <p>Results</p> <p>Smoke exposure decreased BMC and BMD, increased bone turnover (inhibited bone formation and stimulated its resorption), affected bone histomorphometry (increased trabecular separation and osteoclast surface per bone surface; decreased trabecular bone volume, trabecular thickness, trabecular number, cortical thickness, bone formation rate and osteoblast surface per bone surface), and reduced mechanical properties. EPF supplementation during cigarette smoke exposure prevented smoke-induced changes in bone mineral status and bone turnover.</p> <p>Conclusion</p> <p>The results suggest that EPF can prevent the adverse effects of smoke exposure on bone by stimulating bone formation and inhibiting bone turnover and bone resorption.</p>http://www.biomedcentral.com/1471-2474/13/105Smoking<it>Epimedium pubescen</it> flavonoidBone mineral densityBone mineral contentBone turnoverBone histomorphometry |
| spellingShingle | Gao Shu-guang Cheng Ling Li Kang-hua Liu Wen-He Xu Mai Jiang Wei Wei Li-Cheng Zhang Fang-jie Xiao Wen-feng Xiong Yi-lin Tian Jian Zeng Chao Sun Jin-peng Xie Qiang Lei Guang-hua Effect of <it>epimedium pubescen</it> flavonoid on bone mineral status and bone turnover in male rats chronically exposed to cigarette smoke BMC Musculoskeletal Disorders Smoking <it>Epimedium pubescen</it> flavonoid Bone mineral density Bone mineral content Bone turnover Bone histomorphometry |
| title | Effect of <it>epimedium pubescen</it> flavonoid on bone mineral status and bone turnover in male rats chronically exposed to cigarette smoke |
| title_full | Effect of <it>epimedium pubescen</it> flavonoid on bone mineral status and bone turnover in male rats chronically exposed to cigarette smoke |
| title_fullStr | Effect of <it>epimedium pubescen</it> flavonoid on bone mineral status and bone turnover in male rats chronically exposed to cigarette smoke |
| title_full_unstemmed | Effect of <it>epimedium pubescen</it> flavonoid on bone mineral status and bone turnover in male rats chronically exposed to cigarette smoke |
| title_short | Effect of <it>epimedium pubescen</it> flavonoid on bone mineral status and bone turnover in male rats chronically exposed to cigarette smoke |
| title_sort | effect of it epimedium pubescen it flavonoid on bone mineral status and bone turnover in male rats chronically exposed to cigarette smoke |
| topic | Smoking <it>Epimedium pubescen</it> flavonoid Bone mineral density Bone mineral content Bone turnover Bone histomorphometry |
| url | http://www.biomedcentral.com/1471-2474/13/105 |
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