Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression
The urgency of the search for inexpensive and effective drugs with localized action for the treatment of rheumatoid arthritis continues unabated. In this study, for the first time we investigated the Cytos-11 antisense oligonucleotide suppression of TNF-α gene expression in a rat model of rheumatoid...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/3/1022 |
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| author | Tatyana P. Makalish Ilya O. Golovkin Volodymyr V. Oberemok Kateryna V. Laikova Zenure Z. Temirova Olesya A. Serdyukova Ilya A. Novikov Roman A. Rosovskyi Andrey I. Gordienko Evgeniya Yu. Zyablitskaya Elvina A. Gafarova Kseniya A. Yurchenko Iryna I. Fomochkina Anatoly V. Kubyshkin |
| author_facet | Tatyana P. Makalish Ilya O. Golovkin Volodymyr V. Oberemok Kateryna V. Laikova Zenure Z. Temirova Olesya A. Serdyukova Ilya A. Novikov Roman A. Rosovskyi Andrey I. Gordienko Evgeniya Yu. Zyablitskaya Elvina A. Gafarova Kseniya A. Yurchenko Iryna I. Fomochkina Anatoly V. Kubyshkin |
| author_sort | Tatyana P. Makalish |
| collection | DOAJ |
| description | The urgency of the search for inexpensive and effective drugs with localized action for the treatment of rheumatoid arthritis continues unabated. In this study, for the first time we investigated the Cytos-11 antisense oligonucleotide suppression of TNF-α gene expression in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant. Cytos-11 has been shown to effectively reduce peripheral blood concentrations of TNF-α, reduce joint inflammation, and reduce pannus development. The results achieved following treatment with the antisense oligonucleotide Cytos-11 were similar to those of adalimumab (Humira<sup>®</sup>); they also compared favorably with those results, which provides evidence of the promise of drugs based on antisense technologies in the treatment of this disease. |
| first_indexed | 2024-03-09T04:10:31Z |
| format | Article |
| id | doaj.art-402f253cd07243aca857d0963043398f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:10:31Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-402f253cd07243aca857d0963043398f2023-12-03T14:00:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-01223102210.3390/ijms22031022Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α ExpressionTatyana P. Makalish0Ilya O. Golovkin1Volodymyr V. Oberemok2Kateryna V. Laikova3Zenure Z. Temirova4Olesya A. Serdyukova5Ilya A. Novikov6Roman A. Rosovskyi7Andrey I. Gordienko8Evgeniya Yu. Zyablitskaya9Elvina A. Gafarova10Kseniya A. Yurchenko11Iryna I. Fomochkina12Anatoly V. Kubyshkin13Medical Academy Named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, RussiaMedical Academy Named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, RussiaTaurida Academy, V.I. Vernadsky Crimean Federal University, Vernadsky Av. 4, 295007 Simferopol, RussiaTaurida Academy, V.I. Vernadsky Crimean Federal University, Vernadsky Av. 4, 295007 Simferopol, RussiaMedical Academy Named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, RussiaTaurida Academy, V.I. Vernadsky Crimean Federal University, Vernadsky Av. 4, 295007 Simferopol, RussiaTaurida Academy, V.I. Vernadsky Crimean Federal University, Vernadsky Av. 4, 295007 Simferopol, RussiaTaurida Academy, V.I. Vernadsky Crimean Federal University, Vernadsky Av. 4, 295007 Simferopol, RussiaMedical Academy Named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, RussiaMedical Academy Named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, RussiaMedical Academy Named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, RussiaMedical Academy Named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, RussiaMedical Academy Named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, RussiaMedical Academy Named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, RussiaThe urgency of the search for inexpensive and effective drugs with localized action for the treatment of rheumatoid arthritis continues unabated. In this study, for the first time we investigated the Cytos-11 antisense oligonucleotide suppression of TNF-α gene expression in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant. Cytos-11 has been shown to effectively reduce peripheral blood concentrations of TNF-α, reduce joint inflammation, and reduce pannus development. The results achieved following treatment with the antisense oligonucleotide Cytos-11 were similar to those of adalimumab (Humira<sup>®</sup>); they also compared favorably with those results, which provides evidence of the promise of drugs based on antisense technologies in the treatment of this disease.https://www.mdpi.com/1422-0067/22/3/1022rheumatoid arthritisantisense technologiesTNF-αHumira<sup>®</sup>phosphorothioate oligonucleotidesinflammation |
| spellingShingle | Tatyana P. Makalish Ilya O. Golovkin Volodymyr V. Oberemok Kateryna V. Laikova Zenure Z. Temirova Olesya A. Serdyukova Ilya A. Novikov Roman A. Rosovskyi Andrey I. Gordienko Evgeniya Yu. Zyablitskaya Elvina A. Gafarova Kseniya A. Yurchenko Iryna I. Fomochkina Anatoly V. Kubyshkin Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression International Journal of Molecular Sciences rheumatoid arthritis antisense technologies TNF-α Humira<sup>®</sup> phosphorothioate oligonucleotides inflammation |
| title | Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression |
| title_full | Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression |
| title_fullStr | Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression |
| title_full_unstemmed | Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression |
| title_short | Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression |
| title_sort | anti rheumatic effect of antisense oligonucleotide cytos 11 targeting tnf α expression |
| topic | rheumatoid arthritis antisense technologies TNF-α Humira<sup>®</sup> phosphorothioate oligonucleotides inflammation |
| url | https://www.mdpi.com/1422-0067/22/3/1022 |
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